Evidence map›Paper›PMID 39464878›Full record

ArticleFrontiers in immunology2024

Case report: Progressive multifocal leukoencephalopathy co-occurring with neurosarcoidosis: early brain biopsy and appropriate therapy for PML resulted in a favorable prognosis.

Qiannan Wang, Shintaro Tsuboguchi, Kouichirou Okamoto, Mari Tada, Akiyoshi Kakita, Kazuo Nakamichi, Makoto Oishi, Masato Kanazawa, Osamu Onodera

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In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Qiannan WangDepartment of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
Shintaro TsuboguchiDepartment of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
Kouichirou OkamotoDepartment of Translational Research, Brain Research Institute, Niigata University, Niigata, Japan.
Mari TadaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Kazuo NakamichiDepartment of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan.
Makoto OishiDepartment of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.
Masato KanazawaDepartment of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.
Osamu OnoderaDepartment of Neurology, Brain Research Institute, Niigata University, Niigata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare central nervous system disease caused by JC virus (JCV) infection. Human immunodeficiency virus (HIV) infection is the greatest risk factor for PML. Other immunological diseases, including systemic sarcoidosis, have also been reported as risk factors for PML. Herein, we report a case of PML co-occurring with neurosarcoidosis. Early diagnosis using brain biopsy and appropriate therapeutic interventions achieved favorable outcomes. PML in patients with active intracranial neurosarcoidosis is extremely rare. We believe that it is important to perform brain biopsy at an early stage to allow diagnosis, even for central nervous system involvement with a progressive parenchymal lesion in patients with sarcoidosis, if PML is possible.

Indexed as

BrainCentral Nervous System DiseasesLeukoencephalopathy, Progressive MultifocalSarcoidosisBiopsyFemaleHumansJC VirusMagnetic Resonance ImagingMaleMiddle AgedPrognosisTreatment Outcomeavoiding immunosuppressive therapybrain biopsyfavorable prognosisneurosarcoidosisPML

Identifiers

PMID39464878
PMCPMC11502320

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