Evidence map›Paper›PMID 39464835›Full record

ArticleInfection and drug resistance2024

The Endocytosis Adaptor Sla1 Facilitates Drug Susceptibility and Fungal Pathogenesis Through Sla1-Efg1 Regulating System in

Chenhao Suo, Yiru Gao, Sheng Yang, Wanli Zhang, Chao Li, Lanjing Ma, Yingchun Xu, Jianjun Lei, Chen Ding, Hailong Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and drug resistance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Endocytosis Mediated byMicroorganisms · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenhao Suo *Laboratory Animal Department, Northern Theater General Hospital, Shenyang, Liaoning, 110000, People's Republic of China.
Yiru Gao *College of Life and Health Science, Northeastern University, Shenyang, Liaoning, 110000, People's Republic of China.
Sheng YangCollege of Life and Health Science, Northeastern University, Shenyang, Liaoning, 110000, People's Republic of China.
Wanli ZhangCollege of Life and Health Science, Northeastern University, Shenyang, Liaoning, 110000, People's Republic of China.
Chao LiDepartment of Emergency Medicine, the Second Affiliated Hospital of Army Medical University, Chongqing, 400037, People's Republic of China.
Lanjing MaCollege of Life and Health Science, Northeastern University, Shenyang, Liaoning, 110000, People's Republic of China.
Yingchun XuBeijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, 100730, People's Republic of China.
Jianjun LeiLaboratory Animal Department, Northern Theater General Hospital, Shenyang, Liaoning, 110000, People's Republic of China.
Chen DingCollege of Life and Health Science, Northeastern University, Shenyang, Liaoning, 110000, People's Republic of China.ORCID 0000-0002-9195-2255
Hailong LiPulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
He ZhangLaboratory Animal Department, Northern Theater General Hospital, Shenyang, Liaoning, 110000, People's Republic of China.
Tianshu SunBeijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, 100730, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The role of endocytosis in Objective: In order to understand the role of endocytosis in Methods: Detection of intracellular endocytosis by FM4-64 staining; Scanning electron microscopy is used to detect cell wall components; Spot assay for detecting drug sensitivity; Co-ip is used to detect protein interactions. Results: In this study, we found the functions of Sla1 in regulating endocytosis is conserved among pathogenic fungi. Our results also revealed that the deletion of the Discussion: These findings have expanded our knowledge of the capabilities of Sla1 beyond its role as an endocytosis adapter and provided insights into a potential new therapeutic target for the treatment of fungal infections.

Indexed as

cell wall integritydrug susceptibilityendocytosisfungal pathogenicitySla1

Identifiers

PMID39464835
PMCPMC11512525

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.