Evidence map›Paper›PMID 39464779›Full record

ReviewF1000Research2024

The rise of pathogen genomics in Africa.

Gerald Mboowa, Francis Kakooza, Moses Egesa, Stephen Tukwasibwe, Stephen Kanyerezi, Ivan Sserwadda, Benson R Kidenya, Jupiter Marina Kabahita, Maria Magdalene Namaganda, Mike Nsubuga and 5 more

Abstract readReview
In one paragraph

Review in F1000Research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Global Genomic Surveillance.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. The Case for Genomic Surveillance in Africa.Tropical medicine and infectious disease · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gerald MboowaThe African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, College of Health Sciences, Makerere University, P.O. Box 22418, Kampala, Uganda.ORCID https://orcid.org/0000-0001-8445-9414
Francis KakoozaGlobal Health Security, Infectious Diseases Institute, College of Health Sciences, Makerere University, P.O. Box 22418, Kampala, Uganda.
Moses EgesaMRC/UVRI & LSHTM Uganda Research Unit, Entebbe, Uganda.
Stephen TukwasibweSchool of Medicine, Uganda Christian University, Kampala, Uganda.
Stephen KanyereziThe African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, College of Health Sciences, Makerere University, P.O. Box 22418, Kampala, Uganda.ORCID https://orcid.org/0000-0002-2439-939X
Ivan SserwaddaThe African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, College of Health Sciences, Makerere University, P.O. Box 22418, Kampala, Uganda.ORCID https://orcid.org/0000-0001-7785-7297
Benson R KidenyaDepartment of Biochemistry and Molecular Biology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.ORCID https://orcid.org/0000-0001-6056-4156
Jupiter Marina KabahitaNational Tuberculosis Reference Laboratory/Supranational Reference Laboratory, Plot 106-1062 Butabika Road, Luzira, Uganda.
Maria Magdalene NamagandaDepartment of Immunology and Molecular Biology, College of Health Sciences, Makerere University, P.O. Box 77072, Kampala, Uganda.ORCID https://orcid.org/0000-0003-1913-5506
Mike NsubugaThe African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, College of Health Sciences, Makerere University, P.O. Box 22418, Kampala, Uganda.
Patricia NabisubiThe African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, College of Health Sciences, Makerere University, P.O. Box 22418, Kampala, Uganda.ORCID https://orcid.org/0000-0002-1466-695X
Alisen AyitewalaNational Health Laboratories and Diagnostics Services, Central Public Health Laboratories, Ministry of Health, P.O Box 7272, Kampala, Uganda.
Grace KebirungiThe African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, College of Health Sciences, Makerere University, P.O. Box 22418, Kampala, Uganda.
Esther NakafuCollege of Veterinary Medicine, Animal Resources and Bio-security (COVAB), Makerere University, Kampala, Uganda.
Natasha Patience AkwiiDepartment of Plant Sciences, Microbiology and Biotechnology, College of Natural Sciences, Makerere University, Kampala, Uganda.

Funding

NURTURING GENOMICS AND BIOINFORMATICS RESEARCH CAPACITY IN AFRICA (BRecA)U2RTW010672 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI JJINGO, DAUDI, KATEETE, DAVID PATRICK · 2017 to 2022
$1.3M
FIC NIH HHS U2R TW010672
6 · The paper itself

Abstract

The routine genomic surveillance of pathogens in diverse geographical settings and equitable data sharing are critical to inform effective infection control and therapeutic development. The coronavirus disease 2019 (COVID-19) pandemic highlighted the importance of routine genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to detect emerging variants of concern. However, the majority of high-income countries sequenced >0.5% of their COVID-19 cases, unlike low- and middle-income countries. By the end of 2022, many countries around the world had managed to establish capacity for pathogen genomic surveillance. Notably, Beta and Omicron; 2 of the 5 current SARS-CoV-2 variants of concern were first discovered in Africa through an aggressive sequencing campaign led by African scientists. To sustain such infrastructure and expertise beyond this pandemic, other endemic pathogens should leverage this investment. Therefore, countries are establishing multi-pathogen genomic surveillance strategies. Here we provide a catalog of the current landscape of sequenced and publicly shared pathogens in different countries in Africa. Drawing upon our collective knowledge and expertise, we review the ever-evolving challenges and propose innovative recommendations.

Indexed as

COVID-19GenomicsSARS-CoV-2AfricaGenome, ViralHumansAfricaData sharingGenome sequencingPathogen Genomic dataPublic health

Identifiers

PMID39464779
PMCPMC11512136

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.