Evidence map›Paper›PMID 39464774›Full record

ArticleJBMR plus2024

Association between work productivity and characteristics of adults with X-linked hypophosphatemia: an analysis of the XLH disease monitoring program.

Aliya Khan, Ben Johnson, Annabel Nixon, Jennifer E Dent, Zhiyi Li, Erru Yang, Angela Williams

Abstract read
In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aliya KhanMcMaster University, Hamilton, Ontario, L8N 3Z5, Canada.
Ben JohnsonHealth Economics and Outcomes Research, Kyowa Kirin International, Marlow SL7 1HZ, United Kingdom.
Annabel NixonPatient Centered Outcomes, Chilli Consultancy, Salisbury SP1 1JS, United Kingdom.ORCID https://orcid.org/0000-0003-3454-9491
Jennifer E DentPatient Centered Outcomes, Chilli Consultancy, Salisbury SP1 1JS, United Kingdom.
Zhiyi LiHealth Economics and Outcomes Research, Kyowa Kirin North America, Bedminster NJ 07921, United States.
Erru YangGlobal Health Economics and Outcomes Research, Ultragenyx Pharmaceutical Inc., Novato, CA 94949, United States.
Angela WilliamsHealth Economics and Outcomes Research, Kyowa Kirin International, Marlow SL7 1HZ, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

X-linked hypophosphatemia (XLH) is a rare, genetic, progressive, phosphate-wasting disorder that causes skeletal morbidities, stiffness, pain, and impaired physical function. This study used baseline data from the XLH Disease Monitoring Program to evaluate relationships between work productivity and patient characteristics (demographics, medical history, patient-reported, and functional outcomes) in adults with XLH. Bivariate analysis guided the selection of variables for multivariate analysis after adjustment for multicollinearity and conceptual overlap. The analysis comprised 281 subjects (75.4% female; 80.8% from USA; median age 39.2 yr); 53.4% were employed full-time and 31.3% were not employed; 15.3% were receiving disability payments; 47.0% were taking burosumab at study entry. Most employed subjects were working full-time outside the home (69.9%) and in light or sedentary roles (59.6%). In multivariate analyses, patients with fewer orthopedic surgeries (odds ratio [OR] 0.88; 95% confidence interval [CI], 0.81-0.96;

Indexed as

disease monitoring programFGF 23patient-reported outcomeswork productivityX-linked hypophosphatemia (XLH)

Identifiers

PMID39464774
PMCPMC11512684

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.