Evidence map›Paper›PMID 39464723›Full record

ArticleInnovation in aging2024

The High Prevalence and Complexity of Over-the-Counter Medication Misuse in Older Adults.

Jason S Chladek, Aaron M Gilson, Jamie A Stone, Maria E Berbakov, Taylor L Watterson, Elin C Lehnbom, Emily L Hoffins, Katherine A Hemesath, Jukrin Moon, Lauren L Welch and 5 more

Abstract read
In one paragraph

Article in Innovation in aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Prevalence and impact of non-prescription medication misuse in the geriatric population.Exploratory research in clinical and social pharmacy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jason S ChladekDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0003-3382-9352
Aaron M GilsonDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.ORCID https://orcid.org/0000-0002-3627-9627
Jamie A StoneDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.
Maria E BerbakovDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.
Taylor L WattersonDepartment of Pharmacy Systems, Outcomes, and Policy, University of Illinois Chicago College of Pharmacy, Chicago, Illinois, USA.
Elin C LehnbomSonderegger Research Center for Improved Medication Outcomes, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Emily L HoffinsDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.
Katherine A HemesathDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.
Jukrin MoonDepartment of Industrial and Systems Engineering, University of Iowa, Iowa City, Iowa 52242, USA.
Lauren L WelchDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.
Denise L Walbrandt PigarelliDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.
Edward C PortilloDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.
Stephanie M ResendizDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.
Shiying MaiDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.
Michelle A ChuiDivision of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, Madison, Wisconsin, USA.

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
NRSA Training CoreTL1TR002375 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI Vivek Prabhakaran · 2017 to 2026
$8.4M
AHRQ HHS R18 HS027737NCATS NIH HHS TL1 TR002375NCATS NIH HHS UL1 TR002373
6 · The paper itself

Abstract

Background and Objectives: Older adults (≥65 years) are the largest consumers of over-the-counter (OTC) medications and exceptionally vulnerable to the risks of these medications, including adverse drug events (ADEs). However, little is known about how older adults select and use OTCs. This is the first multisite study designed to prospectively quantify the type and intended use of OTCs selected by older adults in community pharmacies where products are purchased. Research Design and Methods: Older adults ( Results: Of the 144 participants, 114 (79%) demonstrated at least one type of misuse when describing how they would use their OTC selections at symptom onset. Drug-drug and drug-label misuse had the highest prevalence. Overall, 26 (18%) and 28 (19%) participants showed only drug-drug or drug-label misuse, respectively. Notably, 55 (38%) of participants demonstrated misuse in 2 or more misuse categories. Misuse potential was exacerbated when participants described treating persistent or worsening symptoms. Discussion and Implications: The results highlight the high prevalence and complexity of OTC misuse in older adults and the need for additional work to improve OTC safety.

Indexed as

Community pharmacyInappropriate medication useMedication safetySelf-careSelf-treatment

Identifiers

PMID39464723
PMCPMC11511907

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.