Evidence map›Paper›PMID 39464461›Full record

ArticleACS omega2024

Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy.

Varsha Karunakaran, Sina Dadgar, Santosh K Paidi, April F Mordi, Whitney A Lowe, Umme Marium Mim, Jesse D Ivers, Joel I Rodriguez Troncoso, Jared A McPeake, Alric Fernandes and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Early Radiation Therapy Response Assessment Using Multi-Scale Photoacoustic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Varsha KarunakaranDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Sina DadgarDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Santosh K PaidiDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.
April F MordiDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Whitney A LoweDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Umme Marium MimDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Jesse D IversDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Joel I Rodriguez TroncosoDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Jared A McPeakeDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Alric FernandesDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Sanidhya D TripathiDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.
Ishan BarmanDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID https://orcid.org/0000-0003-0800-0825
Narasimhan RajaramDepartment of Biomedical Engineering, University of Arkansas, Fayetteville, Arkansas 72701, United States.ORCID https://orcid.org/0000-0003-1224-8567

Funding

Unraveling Gene-Environment Interactions Shaping Metabolism: A Multi-Omics Analysis in DrosophilaP20GM139768 · NIGMS · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI Joanna Fiddler · 2021 to 2026
$17.0M
Wide-Field Short-Wave Infrared (SWIR) multiphoton (MP) tissue imagingP41EB015871 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SO, PETER T. · 2012 to 2021
$11.3M
Determination of functional and molecular biomarkers of treatment resistance with multimodal optical spectroscopyR01CA238025 · NCI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI RAJARAM, NARASIMHAN · 2019 to 2024
$2.0M
Development and testing of a clinically compatible multimodal spectroscopic probe for noninvasive sensing of tumor oxygenation and metabolism in oral cancerR15CA238861 · NCI · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI MULDOON, TIMOTHY J · 2020 to 2020
$419k
NCI NIH HHS R01 CA238025NCI NIH HHS R15 CA238861NIBIB NIH HHS P41 EB015871NIGMS NIH HHS P20 GM139768
6 · The paper itself

Abstract

Treatment resistance is a major bottleneck in the success of cancer therapy. Early identification of the treatment response or lack thereof in patients can enable an earlier switch to alternative treatment strategies that can enhance response rates. Here, Raman spectroscopy was applied to monitor early tumor biomolecular changes in sensitive (UM-SCC-22B) and resistant (UM-SCC-47) head and neck tumor xenografts for the first time in in vivo murine tumor models in response to radiation therapy. We used a validated multivariate curve resolution-alternating least-squares (MCR-ALS) model to resolve complex multicomponent Raman spectra into individual pure spectra and their respective contributions. We observed a significant radiation-induced increase in the contributions of lipid-like species (

Identifiers

PMID39464461
PMCPMC11500151

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.