Evidence map›Paper›PMID 39464304›Full record

ArticleNature. Mental health2024

Building machine learning prediction models for well-being using predictors from the exposome and genome in a population cohort.

Dirk H M Pelt, Philippe C Habets, Christiaan H Vinkers, Lannie Ligthart, Catharina E M van Beijsterveldt, René Pool, Meike Bartels

Abstract read
In one paragraph

Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dirk H M PeltDepartment of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-5926-5247
Philippe C HabetsDepartment of Psychiatry and Anatomy and Neurosciences, Amsterdam University Medical Center location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0001-5831-9020
Christiaan H VinkersAmsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, The Netherlands.ORCID 0000-0003-3698-0744
Lannie LigthartDepartment of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Catharina E M van BeijsterveldtDepartment of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
René PoolDepartment of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Meike BartelsDepartment of Biological Psychology, Faculty of Behavioral and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Funding

Genomics of Developmental Trajectories in TwinsRC2MH089995 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2009 to 2010
$3.8M
Determinants of Adolescent Exercise Behavior; towards Evidence-Based InterventionR01DK092127 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2010 to 2014
$2.2M
Major Depression: Stage 1 Genomewide Association in Population-Based SamplesR01MH081802 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2007 to 2007
$138k
EPA EP-C-15-001NIDDK NIH HHS R01 DK092127NIMH NIH HHS R01 MH081802NIMH NIH HHS RC2 MH089995
6 · The paper itself

Abstract

Effective personalized well-being interventions require the ability to predict who will thrive or not, and the understanding of underlying mechanisms. Here, using longitudinal data of a large population cohort (the Netherlands Twin Register, collected 1991-2022), we aim to build machine learning prediction models for adult well-being from the exposome and genome, and identify the most predictive factors (

Indexed as

Behavioural geneticsHeritable quantitative traitPsychologyQuality of life

Identifiers

PMID39464304
PMCPMC11511667

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.