Evidence map›Paper›PMID 39464218›Full record

ArticleBrain communications2024

Cerebellar activity in PINK1 knockout rats during volitional gait.

Valerie DeAngelo, Justin D Hilliard, Chia-Han Chiang, Jonathan Viventi, George C McConnell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Valerie DeAngeloDepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Justin D HilliardDepartment of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Chia-Han ChiangDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Jonathan ViventiDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
George C McConnellDepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.ORCID https://orcid.org/0000-0002-6243-706X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical models of Parkinson's disease are imperative to gain insight into the neural circuits that contribute to gait dysfunction in advanced stages of the disease. A PTEN-induced putative kinase 1 knockout early-onset model of Parkinson's disease may be a useful rodent model to study the effects of neurotransmitter degeneration caused by a loss of PTEN-induced putative kinase 1 function on brain activity during volitional gait. The goal of this study was to measure changes in neural activity at the cerebellar vermis at 8 months of age. It was found that gait deficits, except run speed, were not significantly different from age-matched wild-type controls, as previously reported. PTEN-induced putative kinase 1 knockout (

Indexed as

cerebellar vermisParkinson’s diseaseμECoG

Identifiers

PMID39464218
PMCPMC11503944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.