Evidence map›Paper›PMID 39464215›Full record

ArticleBrain communications2024

Cerebellar activity in hemi-parkinsonian rats during volitional gait and freezing.

Valerie DeAngelo, Arianna Gehan, Siya Paliwal, Katherine Ho, Justin D Hilliard, Chia-Han Chiang, Jonathan Viventi, George C McConnell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Valerie DeAngeloDepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Arianna GehanDepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Siya PaliwalDepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Katherine HoDepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Justin D HilliardDepartment of Neurosurgery, University of Florida, Gainesville, FL 32611, USA.
Chia-Han ChiangDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Jonathan ViventiDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
George C McConnellDepartment of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.ORCID https://orcid.org/0000-0002-6243-706X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease is a neurodegenerative disease characterized by gait dysfunction in the advanced stages of the disease. The unilateral 6-hydroxydopamine toxin-induced model is the most studied animal model of Parkinson's disease, which reproduces gait dysfunction after >68% dopamine loss in the substantia nigra pars compacta. The extent to which the neural activity in hemi-parkinsonian rats correlates to gait dysfunction and dopaminergic cell loss is not clear. In this article, we report the effects of unilateral dopamine depletion on cerebellar vermis activity using micro-electrocorticography during walking and freezing on a runway. Gait and neural activity were measured in 6-hydroxydopamine- and sham-lesioned rats aged between 4 and 5 months at 14, 21 and 28 days after infusion of 6-hydroxydopamine or control vehicle into the medial forebrain bundle (

Indexed as

6-OHDAcerebellar vermisParkinson’s diseaseμECoG

Identifiers

PMID39464215
PMCPMC11503953

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.