Evidence map›Paper›PMID 39464160›Full record

ArticlebioRxiv : the preprint server for biology2025

Magnesium depletion unleashes two unusual modes of colistin resistance with different fitness costs.

Yu-Ying Phoebe Hsieh, Ian P O'Keefe, Zeqi Wang, Wanting Sun, Hyojik Yang, Linda M Vu, Robert K Ernst, Ajai A Dandekar, Harmit S Malik

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yu-Ying Phoebe HsiehDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.ORCID 0000-0001-8500-3873
Ian P O'KeefeDepartment of Microbial Pathogenesis, University of Maryland - Baltimore, Maryland, USA.
Zeqi WangDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Wanting SunDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Hyojik YangDepartment of Microbial Pathogenesis, University of Maryland - Baltimore, Maryland, USA.
Linda M VuDepartment of Microbial Pathogenesis, University of Maryland - Baltimore, Maryland, USA.
Robert K ErnstDepartment of Microbial Pathogenesis, University of Maryland - Baltimore, Maryland, USA.ORCID 0000-0001-5016-8694
Ajai A DandekarDepartment of Microbiology, University of Washington, Seattle, Washington, USA.ORCID 0000-0002-2992-6523
Harmit S MalikDivision of Basic Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Funding

Colistin-resistant Acinetobacter baumanniiR01AI104895 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI, ERNST, ROBERT K · 2014 to 2024
$4.2M
Pseudomonas aeruginosa sociomicrobiologyR35GM152107 · NIGMS · UNIVERSITY OF WASHINGTON · PI Ajai Dandekar · 2024 to 2026
$1.2M
NIAID NIH HHS R01 AI104895NIGMS NIH HHS R35 GM152107
6 · The paper itself

Abstract

Increasing bacterial resistance to colistin, a vital last-resort antibiotic, is an urgent challenge. We previously reported that magnesium sequestration by

Indexed as

collateral antibiotic sensitivityevolutionary tradeoffsexperimental evolutionlipopolysaccharidesMALDI-TOF mass spectrometrytandem mass spectrometry

Identifiers

PMID39464160
PMCPMC11507728

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.