Evidence map›Paper›PMID 39464137›Full record

ArticlebioRxiv : the preprint server for biology2024

FBXW7 regulates MYRF levels to control myelin capacity and homeostasis in the adult CNS.

Hannah Y Collins, Ryan A Doan, Jiaxing Li, Jason E Early, Megan E Madden, Tyrell Simkins, David A Lyons, Kelly R Monk, Ben Emery

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hannah Y CollinsJungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, Oregon 97239, USA.
Ryan A DoanVollum Institute, Oregon Health & Science University, Portland, Oregon 97239, USA.
Jiaxing LiVollum Institute, Oregon Health & Science University, Portland, Oregon 97239, USA.
Jason E EarlyCentre for Discovery Brain Sciences, MS society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh EH16 4SB, UK.
Megan E MaddenCentre for Discovery Brain Sciences, MS society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh EH16 4SB, UK.
Tyrell SimkinsJungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, Oregon 97239, USA.
David A LyonsCentre for Discovery Brain Sciences, MS society Edinburgh Centre for MS Research, University of Edinburgh, Edinburgh EH16 4SB, UK.
Kelly R MonkVollum Institute, Oregon Health & Science University, Portland, Oregon 97239, USA.
Ben EmeryJungers Center for Neurosciences Research, Department of Neurology, Oregon Health & Science University, Portland, Oregon 97239, USA.

Funding

Control of CNS Myelination by the E3 Ligase Component Fbxw7F31NS122433 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI COLLINS, HANNAH YOUNG · 2022 to 2024
$143k
NINDS NIH HHS F31 NS122433
6 · The paper itself

Abstract

Myelin, along with the oligodendrocytes (OLs) that produce it, is essential for proper central nervous system (CNS) function in vertebrates. Although the accurate targeting of myelin to axons and its maintenance are critical for CNS performance, the molecular pathways that regulate these processes remain poorly understood. Through a combination of zebrafish genetics, mouse models, and primary OL cultures, we found FBXW7, a recognition subunit of an E3 ubiquitin ligase complex, is a regulator of adult myelination in the CNS. Loss of

Identifiers

PMID39464137
PMCPMC11507870

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.