Evidence map›Paper›PMID 39464117›Full record

ArticlebioRxiv : the preprint server for biology2024

Telomere length and cognitive function among middle-aged and older participants from communities underrepresented in aging research: A preliminary study.

Lauren W Y McLester-Davis, Derek Norton, Ligia A Papale, Taryn T James, Hector Salazar, Sanjay Asthana, Sterling C Johnson, Diane C Gooding, Trevor R Roy, Reid S Alisch and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Lauren W Y McLester-DavisUniversity of Wisconsin Native American Center for Health Professions, Department of Biochemistry, Department of Medicine.ORCID 0000-0003-3504-5244
Derek NortonUniversity of Wisconsin Biostatistics and Medical Informatics.
Ligia A PapaleUniversity of Wisconsin Department of Neurological Surgery.
Taryn T JamesUniversity of Wisconsin Department of Medicine.
Hector SalazarUniversity of Pittsburgh School of Nursing.
Sanjay AsthanaUniversity of Wisconsin Department of Medicine.
Sterling C JohnsonUniversity of Wisconsin Department of Psychology.
Diane C GoodingUniversity of Wisconsin Department of Psychology, Department of Medicine, Department of Psychiatry.
Trevor R RoyTulane University School of Medicine.
Reid S AlischUniversity of Wisconsin Department of Neurological Surgery.
Kirk J HoganUniversity of Wisconsin Department of Anesthesiology.
Stacy S DruryBoston Children's Hospital Department of Psychiatry and Behavioral Sciences.
Carey E GleasonUniversity of Wisconsin Department of Medicine, William S. Middleton Memorial Veterans Hospital Geriatric Research Education and Clinical Center.
Megan ZuelsdorffUniversity of Wisconsin School of Nursing.

Funding

Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, JEFFREY A · 2009 to 2018
$16.2M
African Americans Fighting Alzheimer’s in Midlife (AA-FAIM)R01AG054059 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAREY E GLEASON · 2016 to 2026
$15.3M
Elucidating the measurement of telomeres: Development of a transdisciplinary, high-impact Telomere Research NetworkU24AG066528 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI DRURY, STACY SCHMIDT · 2019 to 2023
$3.0M
Social-biological dimensions of ADRD risk and resilience in a Native American cohortR03AG063303 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI ZUELSDORFF, MEGAN · 2019 to 2020
$310k
NIA NIH HHS P30 AG062715NIA NIH HHS P50 AG033514NIA NIH HHS R01 AG054059NIA NIH HHS R03 AG063303NIA NIH HHS U24 AG066528
6 · The paper itself

Abstract

Objective: Accelerated biological aging is a plausible and modifiable determinant of dementia burden facing minoritized communities, but is not well-studied in these historically underrepresented populations. Our objective was to preliminarily characterize relationships between telomere length and cognitive health among American Indian/Alaska Native (AI/AN) and Black/African American (B/AA) middle-aged and older adults. Methods: This study included data on telomere length and cognitive test performance from 187 participants, enrolled in one of two community-based cognitive aging cohorts and who identified their primary race as AI/AN or B/AA. Results: Nested multivariable regression models revealed preliminary evidence for associations between telomere length and cognitive performance, and these associations were partially independent of chronological age. Discussion: Small sample size limited estimate precision, however, findings suggest future work on telomere length and cognitive health in underrepresented populations at high risk for dementia is feasible and valuable as a foundation for social and behavioral intervention research.

Indexed as

Alzheimer’s diseasehealth disparitiesmolecular genetics biological agingrace and ethnicitytelomere length

Identifiers

PMID39464117
PMCPMC11507781

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.