ArticlebioRxiv : the preprint server for biology2024
Human Anti-Glycan Reactivity is Driven by the Selection of B cells Utilizing Private Antibody Gene Rearrangements that are Affinity Maturated in Germinal Centers.
J Stewart New, Christopher F Fucile, Amanda R Callahan, Julia N Burke, Randall S Davis, Wayne L Duck, Alexander F Rosenberg, John F Kearney, R Glenn King
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
J Stewart NewDepartment of Microbiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham AL 35294, USA.
Christopher F FucileInformatics Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Amanda R CallahanDepartment of Microbiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham AL 35294, USA.
Julia N BurkeDepartment of Microbiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham AL 35294, USA.
Randall S DavisDepartment of Medicine, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Wayne L DuckDepartment of Medicine, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35294, USA.
Alexander F RosenbergInformatics Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
John F KearneyDepartment of Microbiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham AL 35294, USA.
R Glenn KingDepartment of Microbiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham AL 35294, USA.ORCID 0000-0001-6522-0053 Funding
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9MVirology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1MTissue and organ specific human B cell immunity: Supplement - Metabolic Risk Factors and Inflammation in PASC DevelopmentU19AI142737 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROSENBERG, ALEXANDER · 2019 to 2023
$19.7MIMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1MRegulation of B cell Clonal Diversity and Its Role in DiseaseR01AI014782 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEARNEY, JOHN FRANKLIN · 1985 to 2020
$7.1MEffects of neonatal microbial exposure on anti-polysaccharide B cell developmentU01AI100005 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEARNEY, JOHN FRANKLIN · 2017 to 2021
$1.9MCommensal-dependent maturation of the natural IgM repertoireF31AI120500 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NEW, JAMES STEWART · 2015 to 2017
$80kNCI NIH HHS P30 CA013148NIAID NIH HHS F31 AI120500NIAID NIH HHS P30 AI027767NIAID NIH HHS R01 AI014782NIAID NIH HHS T32 AI007051NIAID NIH HHS U01 AI100005NIAID NIH HHS U19 AI142737
6 · The paper itselfAbstract
The human antibody repertoire is broadly reactive with carbohydrate antigens represented in the universe of all living things, including both the host/self- as well as the commensal microflora-derived glycomes. Here we have used BCR receptor cloning and expression together with single-cell transcriptomics to analyze the B cell repertoire to the ubiquitous N-acetyl-D-glucosamine (GlcNAc) epitope in human cohorts and dissect the immune phylogeny of this predominant class of antibodies. We find that circulating anti-GlcNAc B cells exhibiting canonical BMem phenotypes emerge rapidly after birth and couple this observation with evidence for germinal center-dependent affinity maturation of carbohydrate-specific B cell receptors
Indexed as
Anti-carbohydrate antibodyB cell repertoireGerminal CenterMemory B cellsN-acetyl-D-glucosamineNeonatal Immunity
Identifiers
PMID39464096
PMCPMC11507706
What OpenQuestion holds
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