Evidence map›Paper›PMID 39464075›Full record

ArticlebioRxiv : the preprint server for biology2024

Farm exposure is associated with human breast milk immune profile and microbiome.

Mary Hannah Swaney, Olivia Rae Steidl, Anastasia Tackett, Samantha Fye, Kristine E Lee, Irene M Ong, Casper Bendixsen, Gretchen Spicer, James DeLine, James E Gern and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mary Hannah SwaneyDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Olivia Rae SteidlDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Anastasia TackettDepartment of Food Science, University of Wisconsin-Madison, Madison, WI, USA.
Samantha FyeDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Kristine E LeeDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
Irene M OngDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
Casper BendixsenNational Farm Medicine Center, Marshfield Clinic Research Institute, Marshfield, WI, USA.
Gretchen SpicerLaFarge Medical Clinic, Vernon Memorial Health Care, LaFarge, WI, USA.
James DeLineLaFarge Medical Clinic, Vernon Memorial Health Care, LaFarge, WI, USA.
James E GernDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.ORCID 0000-0002-6667-4708
John LuceyDepartment of Food Science, University of Wisconsin-Madison, Madison, WI, USA.
Christine M SeroogyDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.
Lindsay KalanDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.ORCID 0000-0003-4980-5128
Anne Marie SinghDepartment of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Wisconsin Infant Study Cohort (WISC)U19AI104317 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, CHRISTINE Marie SEROOGY · 2013 to 2026
$22.5M
Childhood Allergy and the NeOnatal Environment (CANOE) ECHO Pediatric Follow-Up and New EnrollmentUG3OD035509 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI SINGH, ANNE MARIE · 2023 to 2024
$2.8M
Defining the role of cobamides in skin microbiome dynamicsF31AR079846 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI SWANEY, MARY HANNAH · 2022 to 2023
$51k
NCATS NIH HHS UL1 TR002373NIAID NIH HHS U19 AI104317NIAMS NIH HHS F31 AR079846NIH HHS UG3 OD035509
6 · The paper itself

Abstract

Prenatal and early life farm exposure, and breastfeeding, are associated with protection from allergic diseases. We hypothesize that farm exposure influences the human breast milk microbiome and immune proteins. The immune protein profiles and microbial communities of 152 human breast milk samples were compared among three maternal farm exposure groups (traditional agrarian, farm, and non-farm) in rural Wisconsin to identify signatures associated with farm status and atopic disease. We found significant differences between farm groups for 23 immune proteins (p-adj<0.05), microbiome diversity (p=2.2E-05), and microbiome richness (p=8.0e-06). Traditional agrarian human breast milk had the highest immune protein levels and microbiome diversity and richness, followed by farm and non-farm human breast milk. Furthermore, Gram-positive bacterial species correlated with IL-23 mediated signaling events (p-adj<1.0E-05). These data suggest that increased farm exposures promotes human breast milk that is more microbially-diverse and rich in immune-associated proteins, ultimately influencing immune development in the infant.

Indexed as

atopic dermatitisfood allergyhuman breast milkmicrobiome

Identifiers

PMID39464075
PMCPMC11507701

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.