Evidence map›Paper›PMID 39464011›Full record

ArticlebioRxiv : the preprint server for biology2025

Prolonged Hyperactivity Elicits Massive and Persistent Chloride Ion Redistribution in Subsets of Cultured Hippocampal Dentate Granule Cells.

Hajime Takano, Fu-Chun Hsu, Srdjan Joksimovic, Douglas A Coulter

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hajime TakanoDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0003-3033-2412
Fu-Chun HsuDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Srdjan JoksimovicDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Douglas A CoulterDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID 0000-0002-1486-119X

Funding

The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ERIC D MARSH, ROBERT Thomas SCHULTZ · 2021 to 2026
$9.2M
Neuronal Circuit Mechanisms of EpileptogenesisR01NS038572 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI COULTER, DOUGLAS A · 1999 to 2022
$8.0M
Normal and Pathological Function of the Dentate GyrusR01NS082046 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Hajime Takano · 2012 to 2026
$6.1M
NICHD NIH HHS P50 HD105354NINDS NIH HHS R01 NS038572NINDS NIH HHS R01 NS082046
6 · The paper itself

Abstract

Chloride ions play a critical role in neuronal inhibition through the activity of chloride-permeable GABA

Indexed as

chloride ionepilepsyfluorescence lifetime imaging microscopyGaussian mixture modelmodel of epilepsy

Identifiers

PMID39464011
PMCPMC11507851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.