Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jeremy S BianeDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8365-8294
Max A LadowNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Austin FanDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Hye Sun ChoiDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Lexi Zichen ZhouDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Shazreh HassanDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-2731-9698
Daniel L Apodaca-MontanoDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Andrew O KwonDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0009-0004-3398-922X
Joshua X Bratsch-PrinceDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.
Mazen A KheirbekDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9157-7363
Funding
Hippocampal modulation of subcortical circuits in the control of emotional behaviorR01MH108623 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Mazen A Kheirbek · 2016 to 2026
$6.0M
Circuit dynamics supporting associative learning in the dentate gyrusR01DC019813 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A · 2021 to 2025
$2.8M
How is anxiety-related information relayed across hippocampal-prefrontal circuitsR01MH117961 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A, SOHAL, VIKAAS SINGH · 2019 to 2022
$2.3M
Circuit and cellular mechanisms of adult neurogenesis in context encoding and discriminationR01MH111754 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A · 2017 to 2021
The ability to discriminate and categorize the meaning of environmental stimuli and respond accordingly is essential for survival. The ventral hippocampus (vHPC) controls emotional and motivated behaviors in response to environmental cues and is hypothesized to do so in part by deciphering the positive or negative quality of these cues. Yet, what features of the environment are represented in the activity patterns of vCA1 neurons, and whether the positive or negative meaning of a stimulus is present at this stage, remains unclear. Here, using 2-photon calcium imaging across six different experimental paradigms, we consistently found that vCA1 ensembles encode the identity, sensory features, and intensity of learned and innately salient stimuli, but not their overall valence. These results offer a reappraisal of vCA1 function, wherein information corresponding to individual stimulus features and their behavioral saliency predominates, while valence-related information is attached elsewhere.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Representations of stimulus meaning in the hippocampus. · full record | OpenQuestion