Evidence map›Paper›PMID 39464006›Full record

ArticlebioRxiv : the preprint server for biology2024

Suppressing PDGFRβ Signaling Enhances Myocyte Fusion to Promote Skeletal Muscle Regeneration.

Siwen Xue, Abigail M Benvie, Jamie E Blum, Nikolai J Kolba, Benjamin D Cosgrove, Anna Thalacker-Mercer, Daniel C Berry

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siwen XueThe Divisional of Nutritional Sciences at Cornell University, Ithaca, NY.
Abigail M BenvieThe Divisional of Nutritional Sciences at Cornell University, Ithaca, NY.
Jamie E BlumThe Divisional of Nutritional Sciences at Cornell University, Ithaca, NY.
Nikolai J KolbaThe Divisional of Nutritional Sciences at Cornell University, Ithaca, NY.
Benjamin D CosgroveMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY.ORCID 0000-0003-2164-350X
Anna Thalacker-MercerThe Divisional of Nutritional Sciences at Cornell University, Ithaca, NY.
Daniel C BerryThe Divisional of Nutritional Sciences at Cornell University, Ithaca, NY.ORCID 0000-0002-5200-1182

Funding

Deciphering age-dependent beige adipocyte failureR01DK132264 · NIDDK · CORNELL UNIVERSITY · PI Daniel C. Berry · 2022 to 2026
$2.1M
NIDDK NIH HHS R01 DK132264
6 · The paper itself

Abstract

Muscle cell fusion is critical for forming and maintaining multinucleated myotubes during skeletal muscle development and regeneration. However, the molecular mechanisms directing cell-cell fusion are not fully understood. Here, we identify platelet-derived growth factor receptor beta (PDGFRβ) signaling as a key modulator of myocyte fusion in adult muscle cells. Our findings demonstrate that genetic deletion of

Identifiers

PMID39464006
PMCPMC11507758

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.