Evidence map›Paper›PMID 39463991›Full record

ArticlebioRxiv : the preprint server for biology2025

Chronic obesity does not alter cancer incidence in

Ilaria Panzeri, Zachary Madaj, Luca Fagnocchi, Stefanos Apostle, Megan Tompkins, Galen Hostetter, J Andrew Pospisilik

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ilaria PanzeriDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-4139-8591
Zachary MadajBioinformatics and Biostatistics Core, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0003-2330-0500
Luca FagnocchiDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-9551-5474
Stefanos ApostleDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0001-7257-7421
Megan TompkinsVivarium and Transgenics Core, Van Andel Institute, Grand Rapids, MI, USA.
Galen HostetterPathology and Biorepository Core, Van Andel Institute, Grand Rapids, MI, USA.
J Andrew PospisilikDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-9745-0977

Funding

Master regulators of unexplained variation in disease riskR01HG012444 · NHGRI · VAN ANDEL RESEARCH INSTITUTE · PI NADEAU, JOSEPH H., POSPISILIK, JOHN ANDREW · 2021 to 2025
$9.6M
A Trim28-ERV axis drives phenotypic variation in obesityR01DK132216 · NIDDK · VAN ANDEL RESEARCH INSTITUTE · PI POSPISILIK, JOHN ANDREW, SCHONES, DUSTIN EDWARD · 2023 to 2025
$1.8M
NHGRI NIH HHS R01 HG012444NIDDK NIH HHS R01 DK132216
6 · The paper itself

Abstract

Obesity is a complex chronic disease characterized by excessive adiposity and associations with numerous co-morbidities, including cancer. Despite extensive research, we have limited understanding of the mechanisms coupling obesity to cancer risk, and separately, of the contexts where obesity does or does not exacerbate disease. Here, we show that chronic high-fat diet induced obesity has no significant effect on the

Indexed as

Cancerhigh-fat dietLi-Fraumeniobesityp53Trp53R270H

Identifiers

PMID39463991
PMCPMC11507782

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.