Evidence map›Paper›PMID 39463947›Full record

ArticlebioRxiv : the preprint server for biology2024

YebC2 resolves ribosome stalling at polyprolines independent of EF-P and the ABCF ATPase YfmR.

Hye-Rim Hong, Cassidy R Prince, Letian Wu, Isabella N Lin, Heather A Feaga

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Hye-Rim HongDepartment of Microbiology, Cornell University, Ithaca, NY 14853.ORCID 0000-0002-8339-3190
Cassidy R PrinceDepartment of Microbiology, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-2740-522X
Letian WuDepartment of Microbiology, Cornell University, Ithaca, NY 14853.ORCID 0009-0005-9029-3840
Isabella N LinDepartment of Microbiology, Cornell University, Ithaca, NY 14853.ORCID 0009-0003-9491-1971
Heather A FeagaDepartment of Microbiology, Cornell University, Ithaca, NY 14853.ORCID 0009-0007-3190-5135

Funding

Ribosome Quality Control Mechanisms in Gram-Positive BacteriaR35GM147049 · NIGMS · CORNELL UNIVERSITY · PI Heather Feaga · 2022 to 2026
$1.9M
NIGMS NIH HHS R35 GM147049
6 · The paper itself

Abstract

Polyproline motifs are essential structural features of many proteins, and recent evidence suggests that EF-P is one of several factors that facilitate their translation. For example, YfmR was recently identified as a protein that prevents ribosome stalling at proline-containing sequences in the absence of EF-P. Here, we show that the YebC-family protein YebC2 (formerly YeeI) functions as a translation factor in

Identifiers

PMID39463947
PMCPMC11507958

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.