Evidence map›Paper›PMID 39463931›Full record

ArticlebioRxiv : the preprint server for biology2024

Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates.

Michael S Totty, Rita Cervera Juanes, Svitlana V Bach, Lamya Ben Ameur, Madeline R Valentine, Evan Simons, McKenna Romac, Hoa Trinh, Krystal Henderson, Ishbel Del Rosario and 9 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Michael S TottyDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-9292-8556
Rita Cervera JuanesDepartment of Translational Neuroscience, Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.ORCID 0000-0002-0001-3640
Svitlana V BachLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0003-1134-9585
Lamya Ben AmeurVollum Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-2975-8822
Madeline R ValentineLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0001-6078-2794
Evan SimonsDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.ORCID 0000-0002-3228-7320
McKenna RomacDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.ORCID 0009-0005-4493-6438
Hoa TrinhVollum Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-7402-5628
Krystal HendersonDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.
Ishbel Del RosarioLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0001-6225-0660
Madhavi TippaniLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-6465-6418
Ryan A MillerLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Joel E KleinmanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-4210-6052
Stephanie Cerceo PageLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-1951-7398
Arpiar SaundersVollum Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0001-7540-7452
Thomas M HydeLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-8746-3037
Keri MartinowichLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID 0000-0002-5237-0789
Stephanie C HicksDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID 0000-0002-7858-0231
Vincent D CostaDivision of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA.ORCID 0000-0002-5412-8945

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Regulation of neural activity in fear circuits by promoter IV derived BDNFR01MH105592 · NIMH · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2015 to 2024
$5.6M
Registration of spatial gene expression in key nodes of reward-related circuitry in the human brainR01DA053581 · NIDA · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2021 to 2025
$3.7M
Distinguishing preexistent and induced epigenetic risk for alcohol use disordersR01AA026278 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CERVERA JUANES, RITA P · 2019 to 2023
$3.2M
Neurocomputational mechanisms of explore-exploit decision making in prefrontal and motivational neural circuitsR01MH125824 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI COSTA, VINCENT D · 2021 to 2025
$3.2M
Identifying new targets for the treatment of alcohol dependence and relapse: epigenetic analysis of the abstinent brainR01AA027552 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CERVERA JUANES, RITA P · 2020 to 2024
$2.6M
Neural substrates of extinction deficits in pathological fearF32MH135620 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Michael Totty · 2023 to 2026
$224k
NIAAA NIH HHS R01 AA026278NIAAA NIH HHS R01 AA027552NIDA NIH HHS R01 DA053581NIH HHS P51 OD011092NIH HHS P51 OD011132NIMH NIH HHS F32 MH135620NIMH NIH HHS R01 MH105592NIMH NIH HHS R01 MH125824
6 · The paper itself

Abstract

The amygdaloid complex mediates learning, memory, and emotions. Understanding the cellular and anatomical features that are specialized in the amygdala of primates versus other vertebrates requires a systematic, anatomically-resolved molecular analysis of constituent cell populations. We analyzed five nuclear subdivisions of the primate amygdala with single-nucleus RNA sequencing in macaques, baboons, and humans to examine gene expression profiles for excitatory and inhibitory neurons and confirmed our results with single-molecule FISH analysis. We identified distinct subtypes of

Identifiers

PMID39463931
PMCPMC11507838

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.