Evidence map›Paper›PMID 39463733›Full record

ArticleFrontiers in pediatrics2024

The cardiopulmonary benefits of physiologically based cord clamping persist for at least 8 hours in lambs with a diaphragmatic hernia.

Paige J Riddington, Philip L J DeKoninck, Marta Thio, Calum T Roberts, Risha Bhatia, Janneke Dekker, Aidan J Kashyap, Benjamin J Amberg, Karyn A Rodgers, Alison M Thiel and 5 more

Abstract read
In one paragraph

Article in Frontiers in pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Care of the Newborn and Cord During the Third Stage of Labour (Scientific Impact Paper No. 78).BJOG : an international journal of obstetrics and gynaecology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Paige J RiddingtonThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Philip L J DeKoninckThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Marta ThioNewborn Research Centre, The Royal Women's Hospital, Parkville, VIC, Australia.
Calum T RobertsThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Risha BhatiaMonash Newborn, Monash Children's Hospital, Clayton, VIC, Australia.
Janneke DekkerThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Aidan J KashyapThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Benjamin J AmbergThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Karyn A RodgersThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Alison M ThielThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Ilias NitsosThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Valerie A ZahraThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Ryan J HodgesThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Stuart B HooperThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Kelly J CrossleyThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Infants with congenital diaphragmatic hernia can suffer severe respiratory insufficiency and pulmonary hypertension after birth. Aerating the lungs before removing placental support (physiologically based cord clamping, PBCC) increases pulmonary blood flow (PBF) and reduces pulmonary vascular resistance (PVR) in lambs with a diaphragmatic hernia (DH). We hypothesized that these benefits of PBCC persist for at least 8 h after birth. Methods: At ∼138 days of gestation age (dGA), 21 lambs with a surgically induced left-sided DH (∼86 dGA) were delivered via cesarean section. The umbilical cord was clamped either before ventilation onset (immediate cord clamping, ICC, Results: PBF increased after ventilation onset in both groups and was higher in the PBCC DH lambs than the ICC DH lambs at 8 h (5.2 ± 1.2 vs. 1.9 ± 0.3 ml/min/g; Conclusion: Compared with ICC, PBCC increased PBF and reduced PVR in DH lambs and the effects were sustained for at least 8 h after ventilation onset.

Indexed as

congenital diaphragmatic hernialung hypoplasianeonatal transitionpulmonary blood flowpulmonary hypertensionpulmonary vascular resistance

Identifiers

PMID39463733
PMCPMC11502373

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.