Evidence map›Paper›PMID 39463575›Full record

ArticleCureus2024

Clogged Arteries, Safety Net Holes: Treating an Underinsured Patient for Homozygous Familial Hypercholesterolemia With Plasmapheresis.

Parth Patel, Iheoma Alinnor, Mary Ann Kirkconnell Hall, Lance T Hall, Stacey Watkins

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Parth PatelDivision of Hospital Medicine, Emory University School of Medicine, Atlanta, USA.
Iheoma AlinnorDivision of Hospital Medicine, Emory University School of Medicine, Atlanta, USA.
Mary Ann Kirkconnell HallDivision of Hospital Medicine, Emory University School of Medicine, Atlanta, USA.
Lance T HallDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, USA.
Stacey WatkinsDivision of Hospital Medicine, Emory University School of Medicine, Atlanta, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case report explores the difficulties with rapid lipid-lowering therapies in a resource-limited setting. We present a case of an individual with previously diagnosed homozygous familial hypercholesterolemia presenting with anginal chest pain concerning for non-ST elevation myocardial infarction (NSTEMI), with a low-density lipoprotein (LDL) of 984 mg/dL (reference range: 100-129 mg/dL) and a reversible perfusion defect on his nuclear medicine stress test. In addition to the standard treatment for NSTEMI, including cardiac catheterization, the patient was initiated on a proprotein convertase subtilisin/kexin type 9 inhibitor and underwent two rounds of plasmapheresis, which effectively and rapidly lowered his LDL levels.

Indexed as

apheresishomozygous familial hypercholesterolemialow density lipoprotein-cholesterollow density lipoprotein cholesterol plasmapheresistherapeutic plasmapheresis

Identifiers

PMID39463575
PMCPMC11506492

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.