Evidence map›Paper›PMID 39463413›Full record

ArticleEye (London, England)2025

Sodium bicarbonate use in the treatment of idiopathic intracranial hypertension.

Mikayla J Baker, Ziou Jiang, Collin McClelland, Michael S Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mikayla J BakerDepartment of Ophthalmology & Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-5213-8552
Ziou JiangBiostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.
Collin McClellandDepartment of Ophthalmology & Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.
Michael S LeeDepartment of Ophthalmology & Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA. mikelee@umn.edu.ORCID 0000-0003-2691-4532

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
UNIVERSITY OF MINNESOTA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE (UMN CTSI)UL1RR033183 · NCRR · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2011 to 2011
$8.9M
NCATS NIH HHS UL1 TR000114NCRR NIH HHS UL1 RR033183U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) 8 UL1 TR000114-02
6 · The paper itself

Abstract

purposeThis retrospective case-control study from 2008 to 2022 aimed to determine the effect of adjunctive sodium bicarbonate (NaHCO SUBJECTS/

methodsRetrospective data was collected via chart review. 288 eyes of 144 patients with IIH, including those taking ACZ alone (control group, n = 89) vs. ACZ and NaHCO

resultsCox proportional hazards model for the primary outcome yielded a hazard ratio of 0.800, which was statistically insignificant (95% CI, 0.57-1.13; p = 0.200). There was no significant difference between groups when comparing RNFL, VFMD, VA, surgical intervention, or discontinuation of ACZ. The treatment group was more likely to experience side effects from ACZ prior to starting sodium bicarbonate therapy (p < 0.001). Among the treatment group, 92.7% remained on NaHCO

conclusionSodium bicarbonate does not appear to impact treatment outcomes in patients taking acetazolamide for IIH. Sodium bicarbonate may represent a reasonable adjunctive medication to help mitigate acetazolamide-related side effects in this group of patients.

Indexed as

AcetazolamidePseudotumor CerebriSodium BicarbonateAdultCarbonic Anhydrase InhibitorsCase-Control StudiesFemaleHumansMaleMiddle AgedRetinal Ganglion CellsRetrospective StudiesTomography, Optical CoherenceTreatment OutcomeVisual AcuityVisual FieldsAcetazolamideCarbonic Anhydrase InhibitorsSodium Bicarbonate

Identifiers

PMID39463413
PMCPMC11750981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.