Evidence map›Paper›PMID 39463411›Full record

ArticleScientific reports2024

Synthetic data for privacy-preserving clinical risk prediction.

Zhaozhi Qian, Thomas Callender, Bogdan Cebere, Sam M Janes, Neal Navani, Mihaela van der Schaar

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  11. AI and innovation in clinical trials.NPJ digital medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhaozhi Qian *University of Cambridge, Cambridge, CB2 1TN, UK.
Thomas Callender *University College London, London, WC1E 6BT, UK.
Bogdan CebereUniversity of Cambridge, Cambridge, CB2 1TN, UK.
Sam M JanesUniversity College London, London, WC1E 6BT, UK.
Neal NavaniUniversity College London, London, WC1E 6BT, UK.
Mihaela van der SchaarUniversity of Cambridge, Cambridge, CB2 1TN, UK. mv472@cam.ac.uk.

Funding

Cancer Research UK EICEDAAP\100012
6 · The paper itself

Abstract

Synthetic data promise privacy-preserving data sharing for healthcare research and development. Compared with other privacy-enhancing approaches-such as federated learning-analyses performed on synthetic data can be applied downstream without modification, such that synthetic data can act in place of real data for a wide range of use cases. However, the role that synthetic data might play in all aspects of clinical model development remains unknown. In this work, we used state-of-the-art generators explicitly designed for privacy preservation to create a synthetic version of ever-smokers in the UK Biobank before building prognostic models for lung cancer under several data release assumptions. We demonstrate that synthetic data can be effectively used throughout the medical prognostic modeling pipeline even without eventual access to the real data. Furthermore, we show the implications of different data release approaches on how synthetic biobank data could be deployed within the healthcare system.

Indexed as

PrivacyBiological Specimen BanksFemaleHumansInformation DisseminationLung NeoplasmsMalePrognosisUnited KingdomMachine learningRisk-predictionSynthetic data

Identifiers

PMID39463411
PMCPMC11514179

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.