Evidence map›Paper›PMID 39463212›Full record

ArticleCancer causes & control : CCC2025

The association between body mass index and vulvar and vaginal cancer incidence: findings from a large Norwegian cohort study.

Dagfinn Aune, Marie Nordsletten, Tor Åge Myklebust, Trude Eid Robsahm, Bjørn Steen Skålhegg, Tom Mala, Sheraz Yaqub, Usman Saeed

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In one paragraph

Article in Cancer causes & control : CCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dagfinn AuneDepartment of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway. d.aune@imperial.ac.uk.
Marie NordslettenDepartment of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Oslo, Norway.
Tor Åge MyklebustDepartment of Registration, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
Trude Eid RobsahmDepartment of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
Bjørn Steen SkålheggDivision for Molecular Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Tom MalaDepartment of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Oslo, Norway.
Sheraz YaqubDepartment of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Oslo, Norway.
Usman SaeedDepartment of Gastrointestinal and Paediatric Surgery, Oslo University Hospital, Oslo, Norway.

Funding

World Cancer Research Fund International WCRF 2020/035
6 · The paper itself

Abstract

backgroundThere is limited evidence of potential associations between body mass index (BMI) and risk of vulvar and vaginal cancer. We explored these associations in a large cohort of Norwegian women.

methodsThe analytical dataset included 889,441 women aged 16-75 years at baseline in 1963-1975. Multivariable Cox regression analyses were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between BMI and vulvar and vaginal cancer incidence.

resultsDuring 30.1 million person-years of follow-up, 1748 incident vulvar and 408 incident vaginal cancer cases occurred. The HRs (95% CIs) for vulvar cancer for a BMI of 15- < 18.5, 18.5- < 25, 25- < 30, 30- < 35, ≥ 35 were 0.62 (0.38-1.01), 1.00 (reference), 1.23 (1.10-1.40), 1.43 (1.23-1.66) and 1.72 (1.35-2.20, p

conclusionThese results further support the associations between higher BMI and increased risk of vulvar and vaginal cancers, with suggestive stronger associations between BMI in early adulthood for both cancers and for early-onset vaginal cancer. Further studies are needed to elucidate these findings and investigate the underlying mechanisms.

Indexed as

Body Mass IndexVaginal NeoplasmsVulvar NeoplasmsAdolescentAdultAgedCohort StudiesFemaleHumansIncidenceMiddle AgedNorwayRisk FactorsYoung AdultBody mass indexCohortVaginal cancerVulvar cancer

Identifiers

PMID39463212
PMCPMC11774981

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.