Observational studyBritish journal of haematology2025
Burden of vaso-occlusive crisis, its management and impact on quality of life of Indian sickle cell disease patients.
Observational study in British journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Clinical determinants of severe vaso-occlusive crisis in pediatric sickle cell anemia: a retrospective cohort study.Translational pediatrics · 2026Article
- Article
- Article
- Epidemiology of vaso-occlusive crisis among sickle cell disease patients in India: A community-based multi-centric study.The Indian journal of medical research · 2026Article
- Development of a Novel Patient-Reported Outcome Diary to Capture and Monitor Home-Managed Pain Crises in Patients with Sickle Cell Disease.Advances in therapy · 2026Article
- Orbital vaso-occlusive crisis mimicking an abscess in pediatric sickle cell disease: A diagnostic pitfall.Radiology case reports · 2026Article
- Sickle Cell Disease in Eastern Uttar Pradesh, India: Sociodemographic and Clinical Profile from a Previously Undocumented Area.Journal of racial and ethnic health disparities · 2026Article
- Burden of vaso-occlusive crisis, its management and impact on quality of life of Indian sickle cell disease patients.British journal of haematology · 2025Observational
- Health-Related Quality of Life Measurement in Adults With Sickle Cell Disease in Steady State: Experience of One French Reference Center.Mediterranean journal of hematology and infectious diseases · 2025Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
Sickle cell disease (SCD) with vaso-occlusive pain crisis (VOC) significantly impacts patient well-being and often results in extensive healthcare resource utilization. This study assessed the VOC burden, its management and its impact on patients' quality of life (QoL). A cross-sectional observational study was conducted between November 2021 and June 2022, including 1000 SCD patients from high-prevalence states in India. Data on demographics, clinical characteristics, VOC severity, management and QoL were collected. The study revealed that 33.5% of patients reported at least one VOC episode during the study period. In the year prior to their enrolment, 836 (83.60%) patients reported at least one VOC episode, with an equal proportion of 407/487 (83.6%) adults and 429/513 (83.6%) paediatric patients, reducing their QoL across all domains compared to patients without VOC. Of these, 469/1000 patients (46.9%) experienced ≥3 VOC episodes. Additionally, 764/1000 (76.40%) patients managed their VOCs at healthcare facilities, with 501/1000 (50.1%) requiring inpatient admissions. Further, 71.80% of patients received Hydroxyurea (HU) therapy. The study depicts the severity of the Arab-Indian haplotype in Indian SCD patients visiting healthcare settings based on high VOC burden. This highlights the urgent need for better management strategies and resource allocation for these patients.
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