Evidence map›Paper›PMID 39463140›Full record

ArticleEpilepsia open2024

Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis.

Aleksa Pejovic, Zorica Jokovic, Matthias Koepp, Marko Dakovic, Vladimir Bascarevic, Marija Jovanovic, Nikola Vojvodic, Dragoslav Sokic, Aleksandar J Ristic

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Article in Epilepsia open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aleksa PejovicClinic for Neurology, University Clinical Center of Serbia, Belgrade, Serbia.ORCID https://orcid.org/0000-0003-1721-6011
Zorica JokovicFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0001-7073-3857
Matthias KoeppInstitute of Neurology, University College London, London, UK.ORCID https://orcid.org/0000-0002-4277-8000
Marko DakovicFaculty of Physical Chemistry, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0001-7455-5584
Vladimir BascarevicFaculty of Medicine, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-1490-4567
Marija JovanovicRadiology and Magnetic Resonance Imaging Center, University Clinical Center of Serbia, Belgrade, Serbia.
Nikola VojvodicClinic for Neurology, University Clinical Center of Serbia, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-8433-0319
Dragoslav SokicClinic for Neurology, University Clinical Center of Serbia, Belgrade, Serbia.ORCID https://orcid.org/0000-0003-0226-9727
Aleksandar J RisticClinic for Neurology, University Clinical Center of Serbia, Belgrade, Serbia.ORCID https://orcid.org/0000-0002-7564-1641

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCortical atrophy close to medial temporal structures has been described consistently in patients with temporal lobe epilepsy (TLE). Successful TLE surgery may have a neuroprotective effect preventing further atrophy of temporal and extratemporal cortex. However, the effects of epilepsy surgery on subcortical structures demand additional enlightenment. This work aimed to determine how epilepsy surgery affects volumes of subcortical structures in medically refractory temporal lobe epilepsy patients.

methodsWe compared MRI volumes of subcortical structures in 62 patients with TLE (36 left, 26 right) before and after anterior temporal lobectomy with 38 TLE patients (20 left, 18 right) who were considered to be good surgical candidates and had at least two brain MRIs.

resultsThere were no volume differences in subcortical structures on preoperative and initial MRIs of non-operated TLE patients. At baseline, the ipsilateral thalamus and putamen in TLE patients were marginally smaller than contralateral structures. Operated patients showed a significant postoperative volume reduction in ipsilateral thalamus, putamen, and globus pallidus. In contrast, there were no significant volumetric reductions in non-operated patients longitudinally. There were no volumetric changes associated with different surgical outcomes or different postoperative cognitive outcomes. SIGNIFICANCE: Our study demonstrated postoperative volume loss of thalamus, putamen and globus pallidus ipsilaterally to the side of resection. Our findings suggest surgery-related changes, likely Wallerian degeneration within subcortical networks not related to seizure or cognitive outcome. PLAIN LANGUAGE SUMMARY: We studied 100 patients with epilepsy, comparing those who had surgery to those who did not. After surgery, the thalamus, putamen and globus pallidus on the same side as the surgery shrank significantly, but not in non-surgery patients. This suggests surgery-related changes in deeper brain structures, unrelated to seizure freedom or cognitive outcomes. This research sheds additional light on the response of the subcortical structure to epilepsy surgery, highlighting potential areas for further study.

Indexed as

AtrophyEpilepsy, Temporal LobeGlobus PallidusMagnetic Resonance ImagingPutamenThalamusAdultAnterior Temporal LobectomyFemaleHumansMaleMiddle AgedPostoperative ComplicationsYoung Adultepilepsy surgerysubcortical structurestemporal lobe epilepsyvolumetric analysis

Identifiers

PMID39463140
PMCPMC11633681

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.