Evidence map›Paper›PMID 39462901›Full record

Trial reportObesity (Silver Spring, Md.)2024

Shortened sleep duration impairs adipose tissue adrenergic stimulation of lipolysis in postmenopausal women.

Prachi Singh, Robbie A Beyl, Jacqueline M Stephens, Allison J Richard, Anik Boudreau, R Caitlin Hebert, Robert C Noland, David H Burk, Sujoy Ghosh, Jaroslaw Staszkiewicz and 5 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Prachi SinghPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-7392-9035
Robbie A BeylPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Jacqueline M StephensPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-3796-9531
Allison J RichardPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-9559-4061
Anik BoudreauPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
R Caitlin HebertPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Robert C NolandPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
David H BurkPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Sujoy GhoshPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0002-7601-165X
Jaroslaw StaszkiewiczPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
J Michael SalbaumPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.
Josiane L BroussardDepartment of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, USA.
Marie-Pierre St-OngeDepartment of Medicine, Division of General Medicine and Center of Excellence for Sleep & Circadian Research, Columbia University Irving Medical Center, New York, New York, USA.ORCID https://orcid.org/0000-0003-1354-1749
Eric RavussinPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0003-2129-547X
Kara L MarlattPennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID https://orcid.org/0000-0001-7721-7900

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5M
The role of maternal obesity-driven inflammation and adverse pregnancy outcomes in a mouse model of preeclampsiaP20GM135002 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Timothy Allerton · 2020 to 2026
$18.4M
Mentoring Obesity and Diabetes Research in LouisianaP20GM103528 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2012 to 2015
$8.8M
Mechanisms addressing the causal relationships of sleep, circadian rhythms, and cardiometabolic healthR35HL155670 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARIE-PIERRE ST-ONGE · 2021 to 2026
$5.4M
Time-restricted feeding to mitigate metabolic impairments during circadian misalignmentR01DK125653 · NIDDK · COLORADO STATE UNIVERSITY · PI BROUSSARD, JOSIANE · 2020 to 2024
$3.3M
Cardiovascular risk and circadian misalignment in short sleepers- role of extended eating period.R01HL166306 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Prachi Singh · 2023 to 2026
$3.0M
Sleep stability, weight, and glycemic controlR01DK128154 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LAFERRERE, BLANDINE B, ST-ONGE, MARIE-PIERRE · 2021 to 2023
$972k
Influence of menopause on adipose tissue accumulation and functionK01DK128227 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MARLATT, KARA L. · 2022 to 2022
$125k
NHLBI NIH HHS R01 HL166306NHLBI NIH HHS R01HL166306NHLBI NIH HHS R35 HL155670NHLBI NIH HHS R35HL155670NIDDK NIH HHS K01 DK128227NIDDK NIH HHS K01DK128227NIDDK NIH HHS P30 DK072476NIDDK NIH HHS P30DK072476NIDDK NIH HHS R01 DK125653NIDDK NIH HHS R01DK125653NIDDK NIH HHS R01 DK128154NIDDK NIH HHS R01DK128154NIGMS NIH HHS P20 GM103528NIGMS NIH HHS P20 GM135002NIGMS NIH HHS U54 GM104940NIGMS NIH HHS U54GM104940
6 · The paper itself

Abstract

objectiveThe objective of this study was to examine the changes in adipose tissue lipolytic capacity and insulin signaling in response to shortened sleep duration (SSD) in postmenopausal women.

methodsAdipose tissue from a randomized crossover study of nine healthy postmenopausal women (mean [SD], age: 59 [4] years; BMI: 28.0 [2.6] kg/m

resultsWith SSD, basal glycerol secretion was reduced, and isoproterenol-stimulated lipolysis was attenuated. Insulin concentration-dependent increases in phosphorylated Akt observed in samples after habitual sleep were abrogated after SSD. However, insulin-mediated suppression of lipolysis remained unaltered with changes in sleep duration. Increased transcription of genes involved in adipogenesis and fatty acid metabolism was observed after SSD.

conclusionsSSD blunts adrenergic stimulation of lipolysis without altering insulin-mediated suppression of lipolysis in postmenopausal women. These changes in adipose tissue may potentiate fat gain independent of caloric intake. Therefore, interventions promoting sleep may be considered to mitigate abdominal adiposity in postmenopausal women.

Indexed as

Adipose TissueCross-Over StudiesInsulinLipolysisPostmenopauseAdipogenesisFemaleGlycerolHumansIsoproterenolMiddle AgedSignal TransductionSleepSleep DeprivationSleep DurationGlycerolInsulinIsoproterenol

Identifiers

PMID39462901
PMCPMC11598667

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.