Evidence map›Paper›PMID 39462592›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Elderly-onset Familial Mediterranean Fever Carrying MEFV Exon 10 Variants in a Japanese Patient.

Yuya Fujita, Shotaro Ogawa, Yuya Sumichika, Kenji Saito, Shuhei Yoshida, Haruki Matsumoto, Tomoyuki Asano, Shuzo Sato, Mai Yanagida, Shotaro Naito and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuya FujitaDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Shotaro OgawaDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Yuya SumichikaDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Kenji SaitoDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Shuhei YoshidaDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Haruki MatsumotoDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Tomoyuki AsanoDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Shuzo SatoDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.
Mai YanagidaDepartment of General Internal Medicine, Fukushima Medical University, Japan.
Shotaro NaitoDepartment of General Internal Medicine, Fukushima Medical University, Japan.
Kiyoshi MigitaDepartment of Rheumatology, Fukushima Medical University School of Medicine, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Familial Mediterranean fever (FMF) is the most prevalent hereditary autoinflammatory disease and is caused by the MEFV gene. In patients carrying MEFV exon 10 variants, FMF usually develops at an early age. A 76-year-old Japanese man presented with a periodic fever lasting 2-3 days, chest pain, and abdominal pain. An MEFV gene analysis revealed compoundheterozygous M694I/E148Q/L110P. Colchicine treatment (0.5 mg/day) improved the patient's symptoms. This is the first case report of an elderly Japanese patient with FMF onset in the 70s carrying the MEFV exon 10 variant.

Indexed as

Cytoskeletal ProteinsFamilial Mediterranean FeverAgedAge of OnsetColchicineEast Asian PeopleExonsHumansJapanMaleMutationPyrinColchicineCytoskeletal ProteinsMEFV protein, humanPyrinautoinflammatory diseasefamilial Mediterranean feverfever of unknown origin

Identifiers

PMID39462592
PMCPMC12183402

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.