Evidence map›Paper›PMID 39462524›Full record

ArticleOpen heart2024

Mitral-specific cardiac damage score (m-CDS) predicts risk of death in functional mitral regurgitation: a study from the National Echo Database of Australia.

Avalon Moonen, David S Celermajer, Martin Kc Ng, Geoff Strange, David Playford, Simon Stewart

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Open heart, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Avalon MoonenSchool of Medicine, The University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-0039-3911
David S CelermajerSchool of Medicine, The University of Sydney, Sydney, New South Wales, Australia David.Celermajer@health.nsw.gov.au.
Martin Kc NgSchool of Medicine, The University of Sydney, Sydney, New South Wales, Australia.
Geoff StrangeSchool of Medicine, The University of Sydney, Sydney, New South Wales, Australia.
David PlayfordThe University of Notre Dame Australia, Fremantle Campus, Fremantle, Perth, Australia.
Simon StewartThe University of Notre Dame Australia, Fremantle Campus, Fremantle, Perth, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsWe set out to explore associations between a 'mitral-specific' cardiac damage score (m-CDS) and survival outcomes in mitral regurgitation (MR) and compare the performance of the m-CDS and an 'aortic-specific' CDS (a-CDS) in patients with MR within the large National Echo Database of Australia.

methodsAmong 620 831 unique adults investigated with echocardiography, there were 17 658 individuals (3.1%) with moderate or greater functional MR (aged 76±13 years, 51% female) who met inclusion criteria. A randomly selected cohort of 5000 of these patients was used to test seven different CDS models for prediction of subsequent all-cause mortality during an average 3.8-year follow-up. The best-performing CDS model in the

resultsThe best-performing m-CDS model stratified the full cohort into Stage 0: control (1046 patients, 8%); Stage 1: left atrial damage (3416 patients, 27%); Stage 2: left ventricular damage (3352 patients, 26%); Stage 3: right ventricular damage (1551 patients, 12%) and Stage 4: pulmonary hypertension (3293 patients, 26%). Increasing m-CDS stage was consistently and incrementally associated with both all-cause and cardiovascular mortality at 1 year, 5 years and all-time and remained so after adjustment for increasing age and severity of MR, with a ~35% increase in mortality for each increase in CDS stage (p<0.001).

conclusionA m-CDS was robustly and incrementally associated with short-, medium- and long-term risk of all-cause and cardiovascular mortality in patients with functional MR in this large registry study.

Indexed as

Mitral Valve InsufficiencyAgedAged, 80 and overAustraliaCause of DeathDatabases, FactualEchocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedMitral ValvePredictive Value of TestsPrognosisRetrospective StudiesEchocardiographyMitral Valve InsufficiencyVALVULAR DISEASE

Identifiers

PMID39462524
PMCPMC11529689

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