Evidence map›Paper›PMID 39462402›Full record

ArticleGut pathogens2024

CRISPR-Cas system positively regulates virulence of Salmonella enterica serovar Typhimurium.

Nandita Sharma, Ankita Das, Abhilash Vijay Nair, Palash Sethi, Vidya Devi Negi, Dipshikha Chakravortty, Sandhya Amol Marathe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut pathogens, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. TheEcoSal Plus · 2025
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nandita Sharma *Department of Biological Sciences, Birla Institute of Technology & Science, Pilani, Rajasthan, 333031, India.
Ankita Das *Department of Biological Sciences, Birla Institute of Technology & Science, Pilani, Rajasthan, 333031, India.
Abhilash Vijay NairDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, 560012, India.
Palash SethiDepartment of Biological Sciences, Birla Institute of Technology & Science, Pilani, Rajasthan, 333031, India.
Vidya Devi NegiDepartment of Biological Sciences, Indian Institute of Science Education and Research Mohali, Punjab, 140306, India.
Dipshikha ChakravorttyDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, 560012, India.
Sandhya Amol MaratheDepartment of Biological Sciences, Birla Institute of Technology & Science, Pilani, Rajasthan, 333031, India. sandhya.marathe@pilani.bits-pilani.ac.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSalmonella, a foodborne pathogen, possesses a type I-E clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated (Cas) system. We investigated the system's role in regulating Salmonella virulence by deleting the CRISPR arrays and Cas operon.

resultsOur study demonstrates invasion and proliferation defects of CRISPR-Cas knockout strains in intestinal epithelial cells and macrophages owing to the repression of invasion and virulence genes. However, proliferation defects were not observed in the Gp91

conclusionsOverall, our study extends our understanding of the role of the CRISPR-Cas system in Salmonella pathogenesis and its virulence determinants.

Indexed as

Anti-oxidant genesSalmonellaSPI-1-T3SSSPI-2-T3SSType 1-E CRISPR-Cas systemVirulence

Identifiers

PMID39462402
PMCPMC11514906

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.