Evidence map›Paper›PMID 39462387›Full record

Trial reportAntimicrobial resistance and infection control2024

A multicenter study comparing the bacterial reduction on flexible endoscopes without a working channel between UV-C light disinfection versus standard endoscope Washer Disinfection: a randomized controlled trial.

Yana Halmans, D J Wellenstein, M Romijn, A J M van Bemmel, H van den Berge, R A Scheeren, J S Kalpoe, R Klont, J H van Zeijl, H Sikkema and 4 more

Abstract readMulticenter StudyRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Antimicrobial resistance and infection control, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yana HalmansDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center Nijmegen, P/O Box 9101, Nijmegen, The Netherlands. yana.halmans@radboudumc.nl.
D J WellensteinDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center Nijmegen, P/O Box 9101, Nijmegen, The Netherlands.
M RomijnDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center Nijmegen, P/O Box 9101, Nijmegen, The Netherlands.
A J M van BemmelDepartment of Otorhinolaryngology and Head and Neck Surgery, Medical Spectrum Twente, P/O 50000, Enschede, The Netherlands.
H van den BergeDepartment of Otorhinolaryngology and Head and Neck Surgery, Medical Center Leeuwarden, P/O 888, Leeuwarden, The Netherlands.
R A ScheerenDepartment of Otorhinolaryngology, Spaarne Hospital, P/O 417, Haarlem, The Netherlands.
J S KalpoeDepartment of Medical Microbiology, Spaarne Hospital, P/O 417, Haarlem, The Netherlands.
R KlontDepartment of Medical Microbiology, Medical Spectrum Twente, P/O 50000, Enschede, The Netherlands.
J H van ZeijlDepartment of Medical Microbiology, Medical Center Leeuwarden, P/O 888, Leeuwarden, The Netherlands.
H SikkemaDepartment of Hopsital Pharmacy, Medical Center Leeuwarden, P/O 888, Leeuwarden, 8901 BR, The Netherlands.
S M EuserDepartment of Epidemiology and Infection Prevention, Regional Public Health Laboratory Kennemerland, Haarlem, The Netherlands.
J HopmanDepartment of Medical Microbiology, Radboud University Medical Center Nijmegen, P/O Box 9101, Nijmegen, The Netherlands.
R P TakesDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center Nijmegen, P/O Box 9101, Nijmegen, The Netherlands.
G B van den BroekDepartment of Otorhinolaryngology and Head and Neck Surgery, Radboud University Medical Center Nijmegen, P/O Box 9101, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo prevent cross-contamination between patients, adequate reprocessing is necessary when using flexible endoscopes (FEs) without a working channel. The current reprocessing process using an Endoscope Washer Disinfector (EWD) is time-consuming. Ultraviolet light group C (UV-C) exposition is an alternative and fast disinfection method and has previously been shown to adequately reduce Colony Forming Units (CFUs) on FEs without a working channel. The objective of this study was to examine whether UV-C light is as effective in reducing CFUs on contaminated FEs without a working channel compared to the EWD.

methodsFEs without a working channel were collected in three different Otorhinolaryngology Departments in the Netherlands. After pharyngolaryngoscopy, a manual pre-cleaning with tap water was performed and a culture was collected by rolling the distal 8-10 cm of the FE over an agar plate. Next, the FE was randomly assigned to be disinfected with UV-C light (D60) or the EWD (gold standard). After disinfection, another culture was taken. The primary outcome was microbiological contamination, defined by Colony Forming Units (CFU).

results600 FEs without a working channel were randomized. After clinical use and manual pre-cleaning, 239/300 (79.7%) FEs in the UV-C group and 262/300 (87.3%) FEs in the EWD group were contaminated (i.e., > 0 CFU). FEs without culture confirmed contamination were excluded from further analysis. After UV-C light disinfection, 195/239 (81.6%) FEs showed 0 CFUs, compared to 187/262 (71.4%) FEs disinfected with the EWD (p < 0.01). A multivariate logistics regression analysis showed an increased odds of 0 CFUs when using UV-C light (OR 1.83, 95% CI 1.19-2.79; p < 0.01), conditional on participating hospitals and types of FE.

conclusionsUV-C light disinfection of FEs without a working channel appears more effective in reducing CFUs compared to the EWD and might be a good alternative disinfection method.

trial registrationNot applicable.

Indexed as

DisinfectionEndoscopesUltraviolet RaysAdultBacteriaColony Count, MicrobialCross InfectionEquipment ContaminationFemaleHumansMaleMiddle AgedNetherlandsColony forming unitsDisinfectionEndoscope Washer DisinfectorFlexible endoscope without a working channelUltraviolet light CUV-C

Identifiers

PMID39462387
PMCPMC11515285

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.