ArticleJournal of child psychology and psychiatry, and allied disciplines2025
Childhood trajectories of emotional and behavioral difficulties are related to polygenic liability for mood and anxiety disorders.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Gender differences in the association between anxiety and behavioral problems in 31,400 Chinese children: a cross-sectional regression and network analysis.BMC psychiatry · 2026Article
- Editorial: Between emotional regulation and dysregulation: perspectives, interventions, tools and technologies for psychological well-being.Frontiers in behavioral neuroscience · 2026Article
- Polygenic risk and trajectories of depressive symptoms in diverse adolescents: Gene-environment interplay with family conflict and parental acceptance.Development and psychopathology · 2025Article
- Research Review: A review of the past decade of family and genomic studies on adolescent mental health.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
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Authors and funding
15 authors.
Funding
Abstract
backgroundSymptoms related to mood and anxiety disorders (emotional disorders) often present in childhood and adolescence. Some of the genetic liability for mental disorders, and emotional and behavioral difficulties seems to be shared. Yet, it is unclear how genetic liability for emotional disorders and related traits influence trajectories of childhood behavioral and emotional difficulties, and if specific developmental patterns are associated with higher genetic liability for these disorders.
methodsThis study uses data from a genotyped sample of children (n = 54,839) from the Norwegian Mother, Father, and Child Cohort Study (MoBa). We use latent growth models (1.5-5 years) and latent profile analyses (1.5-8 years) to quantify childhood trajectories and profiles of emotional and behavioral difficulties and diagnoses. We examine associations between these trajectories and profiles with polygenic scores for bipolar disorder (PGS
resultsAssociations between PGS
conclusionsGenetic risk for mood disorders and related traits contribute to both a higher baseline level of, and a more rapid increase in, emotional and behavioral difficulties across early and middle childhood, with some indications for disorder-specific profiles. Our findings may inform research on developmental pathways to emotional disorders and the improvement of initiatives for early identification and targeted intervention.
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