ArticleAngewandte Chemie (International ed. in English)2024
An Organometallic Umpolung Approach for Iron-Mediated Propargylic C-H Etherification.
Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Atomically Dispersed Iron-Catalyzed Aerobic Hydroxylation of Allylic and Propargylic C─H Bonds.Angewandte Chemie (International ed. in English) · 2026Article
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4 authors.
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Abstract
Propargylic ethers serve as useful intermediates for the synthesis of a variety of complex targets. However, propargylic substitution of prefunctionalized alkyne starting materials remains the dominant method for the synthesis of propargyl ethers, while direct etherification of simple alkynes via propargylic C-H functionalization remains largely underreported. Herein, we report an organometallic umpolung approach for iron-mediated C-H propargylic etherification. A telescopic protocol for iron-mediated C-H deprotonation followed by mild oxidative coupling with alcohols enabled the use of simple or functionalized alkynes for the expedient synthesis of propargylic ethers with excellent functional group compatibility, chemoselectivity and regioselectivity.
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