Evidence map›Paper›PMID 39462121›Full record

ArticleScientific reports2024

Phytochemical composition, in vitro cytotoxicity, and in silico docking properties of Tamarix tetragyna L.

Bader Huwaimel, Kareem M Younes, Amr S Abouzied, Akram M Elkashlan, Fawaz N Alheibshy, Ahmed Alobaida, Abdullah Turki, Saleh A Alquwaiay, Naif Alqahatani, Sulaiman A Alsuwayagh

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Biogenic FeApplied biochemistry and biotechnology · 2026
    Article
  2. Unveiling the Pharmacological Potential ofInternational journal of molecular sciences · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bader HuwaimelDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, 81442, Saudi Arabia.
Kareem M YounesDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, 81442, Saudi Arabia.
Amr S AbouziedDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail, 81442, Saudi Arabia.
Akram M ElkashlanDepartment of Biochemistry, Faculty of Pharmacy, University of Sadat City, Cairo, Egypt. akram.elkashlan@fop.usc.edu.eg.
Fawaz N AlheibshyDepartment of pharmaceutics, College of Pharmacy, University of Ha'il, Hail, Saudi Arabia.
Ahmed AlobaidaDepartment of pharmaceutics, College of Pharmacy, University of Ha'il, Hail, Saudi Arabia.
Abdullah TurkiCollege of Pharmacy, University of Ha'il, Hail, 81442, Saudi Arabia.
Saleh A AlquwaiayCollege of Pharmacy, University of Ha'il, Hail, 81442, Saudi Arabia.
Naif AlqahataniCollege of Pharmacy, University of Ha'il, Hail, 81442, Saudi Arabia.
Sulaiman A AlsuwayaghCollege of Pharmacy, University of Ha'il, Hail, 81442, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tamarix tetragyna is a plant grows in Mediterranean area and some Arab countries. It possesses numerous medicinal values. Purpose of our study is to explore biological activity of tamarix tetragyna extracts of both leaves and stem with investigating their phytochemical composition. The investigated extracts' phyto-constituent composition was determined using gas chromatographic-mass spectrometric method. In addition, in vitro cytoxicity activity versus cancer cell lines such MCF-7, HepG-2, HCT-116, and A-549 was examined by MTT assay method, together with exploring its apoptosis effect by flow cytometry and western blot analysis techniques. Moreover, some phytochemical compounds were identified, and in-silico evaluated against anticancer molecular targets. Plant extracts showed good cytotoxic activity against both A-549 and HCT-116 cancer cell lines. With an IC

Indexed as

ApoptosisMolecular Docking SimulationPhytochemicalsPlant ExtractsPlant LeavesTamaricaceaeA549 CellsAntineoplastic Agents, PhytogenicCell Line, TumorGas Chromatography-Mass SpectrometryHCT116 CellsHep G2 CellsHumansMCF-7 CellsAntineoplastic Agents, PhytogenicPhytochemicalsPlant Extracts

Identifiers

PMID39462121
PMCPMC11513052

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.