Evidence map›Paper›PMID 39462030›Full record

Trial reportScientific reports2024

Ringer's lactate administered at 15 °C leads to a greater and more prolonged increase in blood pressure compared to 37 °C.

Peter Biesenbach, Michaela Bitten Mølmer, Emilie Lobner Svendsen, Daniel Teichmann, Sophie Wuthe, Mahdi Momeni, Mette Rahbek Kristensen, Line Emilie Laugesen, Gabriele Berg-Beckhoff, Lasse Paludan Bentsen and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Peter BiesenbachResearch Unit in Emergency Medicine, University Hospital of Southern Denmark Esbjerg, Finsensgade 35, 6700, Esbjerg, Region of Southern Denmark, Denmark. peter.biesenbach@rsyd.dk.
Michaela Bitten MølmerDepartment of Emergency Medicine, University Hospital Odense, Odense, Denmark.
Emilie Lobner SvendsenDepartment of Emergency Medicine, University Hospital Odense, Odense, Denmark.
Daniel TeichmannSDU Health Informatics and Technology, The Maersk Mc-Kinney Moller Institute, University of Southern Denmark, Odense, Denmark.
Sophie WutheDepartment of Applied Natural Sciences, Luebeck University of Applied Sciences, Lübeck, Germany.
Mahdi MomeniSDU Health Informatics and Technology, The Maersk Mc-Kinney Moller Institute, University of Southern Denmark, Odense, Denmark.
Mette Rahbek KristensenResearch Unit in Emergency Medicine, University Hospital of Southern Denmark Esbjerg, Finsensgade 35, 6700, Esbjerg, Region of Southern Denmark, Denmark.
Line Emilie LaugesenResearch Unit in Emergency Medicine, University Hospital of Southern Denmark Esbjerg, Finsensgade 35, 6700, Esbjerg, Region of Southern Denmark, Denmark.
Gabriele Berg-BeckhoffDepartment of Public Health, University of Southern Denmark, Odense, Denmark.
Lasse Paludan BentsenDepartment of Emergency Medicine, University Hospital Odense, Odense, Denmark.
Marianne Lerbæk BergmannDepartment of Biochemistry and Immunology, University Hospital of Southern Denmark Vejle, Vejle, Denmark.
Mikkel BrabrandDepartment of Emergency Medicine, University Hospital Odense, Odense, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

18 Participants were randomized to receive 30 ml/kg bodyweight Ringer's Lactate at 37° or 15 °C over 30 min. In a second session, participants were crossed over. Over a 120 min period after starting the fluid bolus we measured mean arterial pressure (MAP), cardiac output, systemic vascular resistance, and catecholamine levels. After infusion with cold fluids, the absolute increase in MAP at 45 min was significantly higher at + 6.5 mmHg (95% CI 4.8-8.2) compared with warm fluids (+ 0.6 mmHg, 95% CI, - 1.6 to 2.8; p < 0.001). This increase in MAP was longer-lasting after cold fluids (81.7 min, 95% CI 62.5-100.9) than after warm fluids (19.2, 95% CI 3.4-35; p < 0.001). While cardiac output was similar, systemic vascular resistance increase was greater after cold fluids (159 dyn s/cm

Indexed as

Blood PressureRinger's LactateAdultArterial PressureCardiac OutputCross-Over StudiesFemaleHumansMaleNorepinephrineTemperatureVascular ResistanceYoung AdultNorepinephrineRinger's LactateBlood pressureFluid bolusNoradrenalinePhysiologyTemperatureVasoconstriction

Identifiers

PMID39462030
PMCPMC11512997

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.