Evidence map›Paper›PMID 39461967›Full record

ArticleNPJ Parkinson's disease2024

Deciphering the effects of STN DBS on neuropsychiatric fluctuations in Parkinson's disease.

Mari Muldmaa, Emmanuelle Schmitt, Roberto Infante, Andrea Kistner, Valérie Fraix, Anna Castrioto, Sara Meoni, Pierre Pélissier, Bettina Debû, Elena Moro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Psychiatric manifestations in Neuronal ceroid lipofuscinoses.Orphanet journal of rare diseases · 2026
    Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mari MuldmaaGrenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble, France.ORCID http://orcid.org/0000-0001-8241-9937
Emmanuelle SchmittGrenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble, France.ORCID http://orcid.org/0000-0002-9044-6131
Roberto InfanteGrenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble, France.
Andrea KistnerGrenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble, France.
Valérie FraixGrenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble, France.ORCID http://orcid.org/0000-0003-4473-9993
Anna CastriotoGrenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble, France.ORCID http://orcid.org/0000-0002-2385-7096
Sara MeoniGrenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble, France.ORCID http://orcid.org/0000-0003-2995-6762
Pierre PélissierGrenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble, France.
Bettina DebûGrenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble, France.ORCID http://orcid.org/0000-0002-2195-8846
Elena MoroGrenoble Alpes University, Movement Disorders Unit, CHU of Grenoble, Grenoble Institute of Neuroscience, Grenoble, France. emoro@chu-grenoble.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The impact of subthalamic nucleus (STN) deep brain stimulation (DBS) on neuropsychiatric fluctuations in Parkinson´s disease (PD) remains unclear. The Neuropsychiatric Fluctuations Scale (NFS) can help to fill this gap, directly measuring fluctuations between the OFF- and ON-medication conditions. The NFS provides NFS-plus (hyperdopaminergic) and NFS-minus (hypodopaminergic) sub-scores. Based on these, the NFS global scores express the overall magnitude of neuropsychiatric symptoms in both the OFF- and ON-medication states. The total fluctuation score (TFS) represents the difference between ON- vs. OFF-medication NFS global scores, thus assessing fluctuations amplitude. The NFS was used to evaluate changes in neuropsychiatric fluctuations between the OFF- and ON-medication conditions before and 1-year after bilateral STN-DBS in 45 PD patients (32 males; mean age, 61.3 ± 7.2 years; PD duration, 10.2 ± 3.0 years). After surgery, the amplitude of neuropsychiatric fluctuations was significantly reduced (p < 0.001), confirming the efficacy of STN-DBS on these symptoms.

Identifiers

PMID39461967
PMCPMC11513077

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.