ArticleNature communications2024
Improving the suppressive power of homing gene drive by co-targeting a distant-site female fertility gene.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Split suppression gene drives reveal a design tradeoff between inheritance and reproductive load inbioRxiv : the preprint server for biology · 2026Article
- RNAi-Mediated Knockdown of Halloween Genes in Lygus hesperus Has Varied Effects on Oogenesis and Fertility.Archives of insect biochemistry and physiology · 2026Article
- Experimental and modeling demonstration of stronger population suppression by gene drive targeting doublesex from dominant female-sterile resistance alleles.Nature communications · 2026Article
- Assessing target genes for homing suppression gene drive.The EMBO journal · 2026Article
- Genetic Allee Effects for Controlling Invasive Populations.Molecular ecology · 2026Article
- Modeling Control of Invasive Fire Ants by Gene Drive.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Maximising Eradication Potential of Rat Gene Drives Using a Two-Target Homing Rescue Strategy: Spatial Modelling of Empirical Data.Molecular ecology · 2025Article
- Gene drive-based population suppression in the malaria vector Anopheles stephensi.Nature communications · 2025Article
- Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila.Nature communications · 2024Article
- Population dynamics in spatial suppression gene drive models and the effect of resistance, density dependence, and life history.bioRxiv : the preprint server for biology · 2024Article
- Germline Cas9 promoters with improved performance for homing gene drive.Nature communications · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene drive technology has the potential to address major biological challenges. Well-studied homing suppression drives have been shown to be highly efficient in Anopheles mosquitoes, but for other organisms, lower rates of drive conversion prevent elimination of the target population. To tackle this issue, we propose a gene drive design that has two targets: a drive homing site where drive conversion takes place, and a distant site where cleavage induces population suppression. We model this design and find that the two-target system allows suppression to occur over a much wider range of drive conversion efficiency. Specifically, the cutting efficiency now determines the suppressive power of the drive, rather than the conversion efficiency as in standard suppression drives. We construct a two-target drive in Drosophila melanogaster and show that both components of the gene drive function successfully. However, cleavage in the embryo from maternal deposition as well as fitness costs in female drive heterozygotes both remain significant challenges for both two-target and standard suppression drives. Overall, our improved gene drive design has the potential to ease problems associated with homing suppression gene drives for many species where drive conversion is less efficient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.