Evidence map›Paper›PMID 39461873›Full record

ArticleRMD open2024

Baseline and 2-year differences in spinal symptoms and spinal and hip mobility in early axial spondyloarthritis and non-axial spondyloarthritis chronic back pain patients.

Ana Bento da Silva, Sofia Ramiro, Miranda van Lunteren, Mary Lucy Marques, Marleen van de Sande, Camilla Fongen, Sofia Exarchou, Roberta Ramonda, Désirée van der Heijde, Floris A van Gaalen

Abstract read
In one paragraph

Article in RMD open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ana Bento da SilvaDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands adbentosilva@gmail.com.ORCID 0000-0002-8590-8119
Sofia RamiroDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-8899-9087
Miranda van LunterenDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-0601-4863
Mary Lucy MarquesDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-3071-9425
Marleen van de SandeDepartment of Rheumatology and Clinical Immunology, Amsterdam University Medical Center, Amsterdam, The Netherlands.ORCID 0000-0003-0966-878X
Camilla FongenDivision of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway.ORCID 0009-0001-4109-3317
Sofia ExarchouDepartment of Clinical Sciences, Rheumatology, Lund University, Malmö, Sweden.ORCID 0000-0002-9261-7192
Roberta RamondaRheumatology Unit, Department of Medicine - DIMED, University of Padova, Padova, Italy.ORCID 0000-0002-9683-8873
Désirée van der HeijdeDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-5781-158X
Floris A van GaalenDepartment of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0001-8448-7407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare spinal symptoms and spinal/hip mobility at baseline and 2 years in early axial spondyloarthritis (axSpA) and non-axSpA chronic back pain (BP) patients.

methodsBaseline and 2 years data of the SPondyloarthritis Caught Early cohort were analysed. Outcomes assessed: overall BP, BP at night, morning stiffness (MS) intensity, MS duration, occiput-to-wall distance (OWD), cervical rotation, chest expansion, lateral spinal flexion (LSF), modified Schober test (mSchober), intermalleolar distance (IMD) and Bath Ankylosing Spondylitis Metrology Index (BASMI). Linear or zero-inflated negative binomial regression was used to compare 2 years outcomes between groups (adjusting for baseline value, sex, age and use of non-steroidal anti-inflammatory drugs).

resultsThere were 294 axSpA and 123 non-axSpA patients (mean symptom duration: 13 months). At baseline, non-axSpA patients had worse symptoms and mobility, except OWD (eg, mean(SD): BP at night 3.6 (2.9) axSpA vs 4.6 (2.7) non-axSpA; OWD 0.5 (1.2) vs 0.1 (0.7)). After 2 years, all symptoms and cervical rotation significantly improved in both groups, but LSF and mSchober only in axSpA. In multivariable analyses, axSpA was associated with larger improvements in BP at night (β (95% CI): -0.85 (-1.47; -0.23)), mSchober (0.26 (0.03; 0.50)), IMD (4.86 (1.93; 7.80)) and BASMI (-0.24 (-0.41; -0.08)), and with lower likelihood of a normal OWD (OR (95% CI): 0.09 (0.01; 0.83)).

conclusionOver 2 years, all spinal symptoms and some mobility measures improved in both groups, but impairments remained prevalent (particularly in non-axSpA). Nevertheless, axSpA was associated with larger improvements in BP at night, mSchober, IMD and BASMI, but with more OWD impairment.

Indexed as

Axial SpondyloarthritisBack PainChronic PainAdultFemaleHumansMaleMiddle AgedRange of Motion, ArticularSeverity of Illness IndexSpineAxial SpondyloarthritisLow Back PainPatient Reported Outcome Measures

Identifiers

PMID39461873
PMCPMC11529763

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.