ArticleThe American journal of clinical nutrition2025
Maternal diet in pregnancy and the risk of inflammatory bowel disease in the offspring: a prospective cohort study.
Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The exposome and inflammatory bowel disease: a framework for primary and primordial prevention.Nature reviews. Gastroenterology & hepatology · 2026Review
- Maternal high-fat diet and risk of cardiovascular disease in offspring: a review of mechanisms, controversies, and interventions.Experimental biology and medicine (Maywood, N.J.) · 2026Review
- Maternal mid-pregnancy dietary patterns and inflammatory bowel disease in offspring from a prospective cohort study.Communications medicine · 2025Article
- Do Italian ObGyn Residents Have Enough Knowledge to Counsel Women About Nutritional Facts? Results of an On-Line Survey.Nutrients · 2025Article
- Impact of maternal organic food consumption and diet quality during pregnancy on offspring's risk of inflammatory bowel disease: findings from a Danish National Birth Cohort Study.Frontiers in nutrition · 2025Article
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7 authors.
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Abstract
backgroundDiet has been hypothesized as a risk factor for the development of inflammatory bowel disease (IBD).
objectiveThe objective of this study was to explore associations between maternal diet diversity and quality in pregnancy and the offspring's risk of IBD.
methodsWe used data from a nationwide cohort study on 85,129 Norwegian children followed from birth (1999-2009) with information on maternal diet in pregnancy from validated food frequency questionnaires. Hazard ratios (HRs) for IBD, Crohn disease (CD), and ulcerative colitis (UC) by maternal diet diversity, quality, and intake amounts of individual food groups were adjusted for maternal BMI, parental IBD, and sociodemographic factors. Sensitivity analyses were adjusted for the child's early-life diet quality and antibiotic treatment. Dietary exposures were classified into tertiles, comparing low (reference) with medium, and high levels.
resultsDuring a mean follow-up time of 16.1 y (1,367,837 person-years of follow-up), 268 children developed IBD (CD, n = 119; UC, n = 76; IBD-unclassified, n = 73). High compared with low diet diversity in pregnancy was associated with a lower risk of UC in the offspring [adjusted HR (aHR) 0.46, 95% confidence interval: 0.25, 0.87], with consistent findings after further adjustment for the child's early-life diet quality and antibiotic treatment. High compared with low diet diversity in pregnancy yielded aHRs of 0.81 for CD (0.51-1.28) and 0.75 for any IBD (0.55-1.02) in the offspring. A high compared with low diet quality in pregnancy or intakes of specific food groups were not associated with the offspring's risk of IBD or its subtypes.
conclusionsOur findings suggest that a higher maternal diet diversity in pregnancy may be associated with a lower risk of UC in the offspring.
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