Evidence map›Paper›PMID 39461049›Full record

ReviewCurrent opinion in chemical biology2024

Microbial metabolite-receptor interactions in the gut microbiome.

Pamela V Chang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  8. The hallmarks of host-microbiome decoupling.Frontiers in microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Pamela V ChangDepartment of Microbiology and Immunology, USA; Department of Chemistry and Chemical Biology, USA; Cornell Center for Immunology, USA; Cornell Institute of Host-Microbe Interactions and Disease, USA; Cornell Center for Innovative Proteomics, Cornell University, Ithaca, NY 14853, USA. Electronic address: pamela.chang@cornell.edu.

Funding

Activity-based protein profiling of gut microbiota-associated bile acid metabolismR35GM133501 · NIGMS · CORNELL UNIVERSITY · PI Pamela Vivian Chang · 2019 to 2026
$2.8M
NIGMS NIH HHS R35 GM133501
6 · The paper itself

Abstract

The gut microbiome impacts many physiological processes that greatly influence host health and disease. Metabolites produced by the gut microbiota have emerged as central players in regulating these biological pathways, often through the engagement of specific host receptors. Despite the importance of these microbial metabolites and receptors in human biology, the vast majority of these interactions remain uncharted due to the complex nature of the gut microbiome and the multitude of metabolites that these microbes produce. Here, we highlight recent developments in identifying such host-gut microbiota interactions, including characterization of bioactive metabolites and their mechanisms of action. Understanding these pathways will enable the development of prophylactics and therapeutics for treating many inflammatory diseases that are impacted by the gut microbiota.

Indexed as

Gastrointestinal MicrobiomeAnimalsHumansBacteriaG-protein coupled receptorsGut microbiomeMetabolitesNuclear receptors

Identifiers

PMID39461049
PMCPMC11588511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.