Evidence map›Paper›PMID 39460938›Full record

ArticleCell reports2024

General anesthesia activates a central anxiolytic center in the BNST.

Dongye Lu, Camille G Uldry Lavergne, Seonmi Choi, Jaehong Park, Jiwoo Kim, Shengli Zhao, Quinn Desimone, Eva Lendaro, Bin Chen, Bao-Xia Han and 2 more

Abstract read
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. A Shared Threat-Anticipation Circuit Is Dynamically Engaged at Different Moments by Certain and Uncertain Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Dongye LuMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Camille G Uldry LavergneMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Seonmi ChoiMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Jaehong ParkMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA.
Jiwoo KimDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Shengli ZhaoDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Quinn DesimoneMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Eva LendaroMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Bin ChenMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Bao-Xia HanDepartment of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Fan WangMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: fan_wang@mit.edu.
Nitsan GoldsteinMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Funding

Identification and Validation of a Novel Central Analgesia CircuitR01DE029342 · NIDCR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATHEW, JOSEPH P, WANG, FAN · 2019 to 2019
$2.9M
NIDCR NIH HHS R01 DE029342
6 · The paper itself

Abstract

Low doses of general anesthetics like ketamine and dexmedetomidine have anxiolytic properties independent of their sedative effects, but the underlying mechanisms remain unclear. We discovered a population of GABAergic neurons in the oval division of the bed nucleus of the stria terminalis that are activated by multiple anesthetics and the anxiolytic drug diazepam (ovBNST

Indexed as

Anesthesia, GeneralAnti-Anxiety AgentsAnxietySeptal NucleiAnimalsBehavior, AnimalDiazepamGABAergic NeuronsMaleMiceMice, Inbred C57BLAnti-Anxiety AgentsDiazepamAnestheticsanxietyanxiolysisBNSTCP: NeurosciencediazepamFosheart rate variability

Identifiers

PMID39460938
PMCPMC11645888

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.