Evidence map›Paper›PMID 39460805›Full record

SynthesisArchives of dermatological research2024

Clinical features and effects of cyclosporine in the treatment of psoriasis: a systemic review and meta-analysis.

Zaibing Li, Baoqiang Pei, Tianbing Lei, Ming Yao, Yanchao Niu, Peimei Zhou, Yonghong Lu, Yan Tang

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Archives of dermatological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zaibing LiDepartment of Dermatology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan, China.
Baoqiang PeiDepartment of Dermatology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan, China.
Tianbing LeiDepartment of Dermatology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan, China.
Ming YaoDepartment of Dermatology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan, China.
Yanchao NiuDepartment of Dermatology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan, China.
Peimei ZhouDepartment of Dermatology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan, China.
Yonghong LuDepartment of Dermatology, Chengdu Second People's Hospital, Chengdu, 610017, Sichuan, China.
Yan TangDepartment of Dermatology, The First People's Hospital of Shuangliu District, Chengdu, 610200, Sichuan, China. 57393920@qq.com.

Funding

the key research and development project of Sichuan science and technology plan 2021YFS0200
6 · The paper itself

Abstract

To systematically evaluate clinical features and effects of cyclosporine in the treatment of psoriasis. Databases including Web of Science, PubMed, The Cochrane Library, Embase, CNKI, Wan Fang, and VIP were electronically searched for studies on the use of cyclosporine in the treatment of psoriasis, from inception to March 2024. Two reviewers independently screened the literature, extracted data, and assessed the risk of bias of the included studies. A meta-analysis was then performed. A total of 12 randomised controlled trial (RCT) studies were included. Compared with the control group, there were statistically significant differences in the effective rate, recurrence rate, erythema regression time, pustular resolution time, fever resolution time, and Psoriasis Area Severity Index (PASI) score of cyclosporine in the treatment of psoriasis. Moreover, the sub-group analysis showed that the effective rate of patients aged less than 40 years was significantly higher than that of the control group and the recurrence rate was significantly lower than that of the control group. The effective rate of psoriasis patients without nail lesions was significantly higher than that of control group. The effective rate of cyclosporin was significantly higher than that of dexamethasone acetate. There was no significant change in pooled sensitivity and specificity after each study was excluded one by one, indicating the stability of the meta-analysis. Cyclosporine had a high effective rate and low recurrence rate in the treatment of psoriasis, but it still had similar rate of adverse reactions compared to other drugs. This study systematically evaluated the effect of cyclosporine in the treatment of psoriasis and provided reference for clinical practice.

Indexed as

CyclosporinePsoriasisAdultDermatologic AgentsHumansImmunosuppressive AgentsRandomized Controlled Trials as TopicRecurrenceSeverity of Illness IndexTreatment OutcomeCyclosporineDermatologic AgentsImmunosuppressive AgentsA systemic reviewClinical effectsClinical featuresCyclosporinePsoriasis

Identifiers

PMID39460805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.