Evidence map›Paper›PMID 39460471›Full record

Observational studyJournal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG2024

Lack of oral involvement in a large cohort of women with vulvar lichen sclerosus - a multicenter prospective study.

Monica Corazza, Camilla Salvini, Valeria Gaspari, Oriana Simonetti, Natale Schettini, Angelina de Magnis, Luca Rapparini, Giulio Rizzetto, Cosimo Misciali, Elisa Marzola and 1 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Lack of oral involvement in a large cohort of women with vulvar lichen sclerosus - a multicenter prospective study.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2024
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Monica CorazzaSection of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Camilla SalviniDermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.
Valeria GaspariDermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy.
Oriana SimonettiDepartment of Clinical and Molecular Sciences, Dermatology Clinic, Polytechnic Marche University, Ancona, Italy.
Natale SchettiniSection of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.ORCID 0000-0002-6693-766X
Angelina de MagnisGinecologia oncologica, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Luca RappariniDermatology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy.ORCID 0000-0002-4029-941X
Giulio RizzettoDepartment of Clinical and Molecular Sciences, Dermatology Clinic, Polytechnic Marche University, Ancona, Italy.
Cosimo MiscialiDepartment of Medical and Surgical Sciences, Dermatology Unit, University of Bologna, Bologna, Italy.
Elisa MarzolaSection of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.ORCID 0000-0002-5905-6186
Alessandro BorghiSection of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.ORCID 0000-0001-9163-9691

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesWe assessed the prevalence of oral lichen sclerosus in a cohort of women affected with vulvar lichen sclerosus (VLS). PATIENTS AND

methodsThis prospective, observational study included adult female patients with a histologically proven VLS who attended the Vulva Clinics of three Dermatology Units from January 2020 to July 2023. During this period, all VLS patients were asked to be examined in their oral cavities in order to detect any possible sign of oral diseases, which were then biopsied.

resultsThree hundred women (mean age 64.5 ± 13.0 years) were included, of whom 21 (7%) had a concurrent extragenital LS. In six (2%) patients, white, non-removable lesions were found at oral inspection and biopsied. All cases were histologically lichen planus. No other clinically relevant oral lesions were found. The six women with histologically proven oral lichen planus had more frequent periodontal and autoimmune diseases than the other included subjects.

conclusionsOur findings confirm the absolute rarity of oral involvement in patients with VLS. They suggest that the oral mucosa, unlike the genitals, is a setting which weakly leads to development of LS, also in predisposed subjects.

Indexed as

Vulvar Lichen SclerosusAdultAgedBiopsyFemaleHumansLichen Planus, OralMiddle AgedPrevalenceProspective Studiesanatomical areachronic inflammatory diseaseslichen planusoral lichen sclerosuspathogenesisVulvar lichen sclerosus

Identifiers

PMID39460471
PMCPMC11626221

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.