Evidence map›Paper›PMID 39460456›Full record

ReviewEuropean journal of neurology2025

Central nervous system crystal-storing histiocytosis: A case report and literature review.

Nabeela Nathoo, Daniel P Larson, Yong Guo, Caterina Giannini, Claudia F Lucchinetti, Ivana N Micallef, Karen L Rech, Dragan Jevremovic, Daniel H Lachance, Jithma P Abeykoon and 2 more

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nabeela NathooDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-6446-1146
Daniel P LarsonDivision of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Yong GuoDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Caterina GianniniDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Claudia F LucchinettiDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Ivana N MicallefDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Karen L RechDivision of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Dragan JevremovicDivision of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Daniel H LachanceDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Jithma P AbeykoonDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Ronald S GoDivision of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
W Oliver TobinDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-8141-2394

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCrystal-storing histiocytosis (CSH) is a rare form of histiocytosis with intralysosomal accumulations of immunoglobulins or paraproteins that aggregate as crystals. Central nervous system (CNS) involvement of CSH is uncommon but should be considered in cases of persistent parenchymal enhancement on neuroimaging.

methodsWe describe one local case of CNS CSH and 10 additional cases identified by literature review.

resultsAmong 11 CSH patients, lesions involved either the dura (2/11) or brain parenchyma (9/11). Two cases had leptomeningeal enhancement. One case had spinal cord involvement. Two cases were associated with marginal zone lymphoma; one case was associated with an immunoglobulin A-plasma cell dyscrasia. Eight of 11 cases had outcome data available: 7/8 cases had clinical and/or radiological improvement and 1/8 had radiological stability.

conclusionsCentral nervous system involvement of CSH is rare. Potential cases should be comprehensively evaluated for lymphoma or myeloma with positron emission tomography/computed tomography (CT) of the body or alternatively, CT of the chest, abdomen, pelvis and nuclear bone scan, bone marrow biopsy, serum protein electrophoresis, and cerebrospinal fluid protein electrophoresis. Treatment is targeted toward the underlying malignancy.

Indexed as

HistiocytosisCentral Nervous System DiseasesHumanscrystal‐storing histiocytosishistiocytic neoplasmlymphomamyelomaparaproteins

Identifiers

PMID39460456
PMCPMC11622262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.