Evidence map›Paper›PMID 39460429›Full record

ArticleChemistryOpen2025

Efficient Cleavage of pUC19 DNA by Tetraaminonaphthols.

Catharina Kost, Ute Scheffer, Elisabeth Kalden, Michael Wilhelm Göbel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Catharina KostInstitut für Organische Chemie und Chemische Biologie, Goethe-Universität, Frankfurt am Main, Max-von-Laue-Str. 7, D-60438, Frankfurt am Main, Germany.
Ute SchefferInstitut für Organische Chemie und Chemische Biologie, Goethe-Universität, Frankfurt am Main, Max-von-Laue-Str. 7, D-60438, Frankfurt am Main, Germany.ORCID 0000-0002-5921-640X
Elisabeth KaldenInstitut für Organische Chemie und Chemische Biologie, Goethe-Universität, Frankfurt am Main, Max-von-Laue-Str. 7, D-60438, Frankfurt am Main, Germany.
Michael Wilhelm GöbelInstitut für Organische Chemie und Chemische Biologie, Goethe-Universität, Frankfurt am Main, Max-von-Laue-Str. 7, D-60438, Frankfurt am Main, Germany.ORCID 0000-0002-5694-4823

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In an attempt to create models of phosphodiesterases, we previously investigated bis(guanidinium) naphthols. Such metal-free anion receptors cleaved aryl phosphates and also plasmid DNA. Observed reaction rates, however, could not compete with those of highly reactive metal complexes. In the present study, we have replaced the guanidines by ethylene diamine side chains which accelerates the plasmid cleavage by compound 13 significantly (1 mM 13: t1/2=22 h). Further gains in reactivity are achieved by azo coupling of the naphthol unit. The electron accepting azo group decreases the pK

Indexed as

DNADNA CleavageNaphtholsPlasmidsKineticsDNANaphtholsAnion receptorAzo naphtholDNA cleavageEnzyme mimicOrganocatalysis

Identifiers

PMID39460429
PMCPMC11808266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.