Evidence map›Paper›PMID 39460379›Full record

ArticleAging cell2025

Early resilience and epigenetic ageing: Results from the prospective Young Finns Study with a 31-year follow-up.

Aino Saarinen, Saara Marttila, Pashupati P Mishra, Leo-Pekka Lyytikäinen, Binisha Hamal Mishra, Emma Raitoharju, Nina Mononen, Mika Kähönen, Olli Raitakari, Terho Lehtimäki and 1 more

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Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aino SaarinenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-4495-8360
Saara MarttilaDepartment of Molecular Epidemiology, Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Pashupati P MishraDepartment of Clinical Chemistry, Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Binisha Hamal MishraDepartment of Clinical Chemistry, Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Emma RaitoharjuDepartment of Molecular Epidemiology, Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Nina MononenDepartment of Clinical Chemistry, Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Liisa Keltikangas-JärvinenDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Funding

Competitive State Research Financing of the Expert Responsibility area of Kuopio, Tampere and Turku University Hospitals X51001CVDLink EU grant nro. 101137278Diabetes Research Foundation of Finnish Diabetes AssociationEmil Aaltosen SäätiöEU Horizon 2020 grant 755320 for TAXINOMISISEU Horizon 2020 grant 848146 for To AitionEuropean Research Council grant 742927 for MULTIEPIGEN projectJuho Vainion SäätiöPaavo Nurmen SäätiöpBETTER4U_EU (Preventing obesity through Biologically and bEhaviorally Tailored inTERventions for you) project number 101080117Research Council of Finland 117797 (Gendi)Research Council of Finland 121584Research Council of Finland 124282Research Council of Finland 126925Research Council of Finland 129378 (Salve)Research Council of Finland 134309 (Eye)Research Council of Finland 141071 (Skidi)Research Council of Finland 286284Research Council of Finland 322098Research Council of Finland 330809Research Council of Finland 338395Research Council of Finland 349708Research Council of Finland 356405Signe ja Ane Gyllenbergin SäätiöSuomen kliinisen kemian yhdistysSuomen KulttuurirahastoSydäntutkimussäätiöTampereen TuberkuloosisäätiöTampere University Hospital Supporting Foundationthe Cancer Foundation Finlandthe Jane and Aatos Erkko FoundationThe Sigrid Juselius Foundationthe Social Insurance Institution of FinlandYrjö Jahnssonin Säätiö
6 · The paper itself

Abstract

Evidence is accumulating on the connection of early adversities and harsh family environment with epigenetic ageing. We investigated whether early psychosocial resilience is associated with epigenetic ageing in adulthood. We used the population-based Young Finns data (n = 1593). Early psychosocial resilience was assessed in 1980-1989 across five broad domains: (1) index of psychological strength (self-esteem at home/in general/at school, perceived possibilities to influence at home, internal life control), (2) index of social satisfaction (perceived support from family/friends and life satisfaction), (3) index of leisure time activities (hobbies and physical fitness), (4) index of responsible health behaviors (infrequent smoking or alcohol consumption), and (5) index of school career (school grades and adaptation). Epigenetic ages were calculated for blood samples from 2011, and the analyses were performed with variables describing age deviation (AgeDev

Indexed as

AgingEpigenesis, GeneticResilience, PsychologicalAdolescentAdultFemaleFinlandFollow-Up StudiesHumansMaleProspective StudiesYoung Adultageingbiological clockepigenetic ageingepigenetic clockresilience

Identifiers

PMID39460379
PMCPMC11822653

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.