Evidence map›Paper›PMID 39460319›Full record

ArticleVaccines2024

Immunogenicity and Protectivity of Sputnik V Vaccine in hACE2-Transgenic Mice against Homologous and Heterologous SARS-CoV-2 Lineages Including Far-Distanced Omicron BA.5.

Inna V Dolzhikova, Amir I Tukhvatulin, Daria M Grousova, Ilya D Zorkov, Marina E Komyakova, Anna A Ilyukhina, Anna V Kovyrshina, Artem Y Shelkov, Andrey G Botikov, Ekaterina G Samokhvalova and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Inna V DolzhikovaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Amir I TukhvatulinFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.ORCID 0000-0001-8506-2339
Daria M GrousovaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.ORCID 0000-0002-3299-4818
Ilya D ZorkovFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Marina E KomyakovaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Anna A IlyukhinaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Anna V KovyrshinaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Artem Y ShelkovFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Andrey G BotikovFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Ekaterina G SamokhvalovaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Dmitrii A ReshetnikovFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.ORCID 0000-0003-3851-8959
Andrey E SiniavinFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.ORCID 0000-0001-7576-2059
Daria M SavinaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.ORCID 0000-0002-2228-3406
Dmitrii V ShcheblyakovFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Fatima M IzhaevaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.ORCID 0000-0002-4110-3941
Alina S DzharullaevaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Alina S ErokhovaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Olga PopovaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Tatiana A OzharovskayaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Denis I ZrelkinFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Polina P GoldovskayaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.ORCID 0009-0000-1965-0482
Alexander S SemikhinFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Olga V ZubkovaFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Andrey A NedorubovFederal State Autonomous Educational Institution of Higher Education "I.M. Sechenov First Moscow State Medical University" (Sechenov University), Ministry of Health, Russian Federation, 119991 Moscow, Russia.
Vladimir A GushchinFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.ORCID 0000-0002-9397-3762
Boris S NaroditskyFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Denis Y LogunovFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.
Alexander L GintsburgFederal State Budget Institution "National Research Centre for Epidemiology and Microbiology Named after Honorary Academician N F Gamaleya", Ministry of Health, Russian Federation, 123098 Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe SARS-CoV-2 virus continuously acquires mutations, leading to the emergence of new variants. Notably, the effectiveness of global vaccination efforts has significantly declined with the rise and spread of the B.1.1.529 (Omicron) variant.

methodsThe study used virological, immunological and histological research methods, as well as methods of working with laboratory animals. In this study, we evaluated the Gam-COVID-Vac (Sputnik V), an adenoviral vaccine developed by the N.F. Gamaleya National Research Center for Epidemiology and Microbiology, and conducted experiments on hemizygous K18-ACE2-transgenic F1 mice. The variants studied included B.1.1.1, B.1.1.7, B.1.351, B.1.1.28/P.1, B.1.617.2, and B.1.1.529 BA.5.

resultsOur findings demonstrate that the Sputnik V vaccine elicits a robust humoral and cellular immune response, effectively protecting vaccinated animals from challenges posed by various SARS-CoV-2 variants. However, we observed a notable reduction in vaccine efficacy against the B.1.1.529 (Omicron BA.5) variant.

conclusionsOur results indicate that ongoing monitoring of emerging mutations is crucial to assess vaccine efficacy against new SARS-CoV-2 variants to identify those with pandemic potential. If protective efficacy declines, it will be imperative to develop new vaccines tailored to current variants of the virus.

Indexed as

COVID-19 vaccinecross-protectionhACE2-transgenic miceimmunogenicityvector vaccine

Identifiers

PMID39460319
PMCPMC11512357

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.