Evidence map›Paper›PMID 39460258›Full record

ArticleVaccines2024

Evaluation of a Quadrivalent

Emily M Boerth, Joyce Gong, Becky Roffler, Zoe Hancock, Lydia Berger, Boni Song, Sasha F Malley, Calman A MacLennan, Fan Zhang, Richard Malley and 1 more

Abstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Development of an 8-valentFrontiers in immunology · 2026
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emily M BoerthDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0002-4011-2923
Joyce GongDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Becky RofflerDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Zoe HancockDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7056-2880
Lydia BergerDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Boni SongDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Sasha F MalleyDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Calman A MacLennanEnteric & Diarrheal Diseases, Global Health, Bill & Melinda Gates Foundation, 500 5th Ave. N, Seattle, WA 98109, USA.
Fan ZhangDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Richard MalleyDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8688-3398
Ying-Jie LuDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1805-3955

Funding

Bill & Melinda Gates Foundation INV-037568
6 · The paper itself

Abstract

backgroundShigellosis is the leading cause of diarrheal deaths worldwide and is particularly dangerous in children under 5 years of age in low- and middle-income countries. Additionally, the rise in antibiotic resistance has highlighted the need for an effective

methodsIn this work, we detail the development of several monovalent vaccines using O-specific polysaccharides (OSPs) from four dominant serotypes,

resultsIndividual MAPS vaccines generated robust, functional antibody responses against both IpaB and the individual OSP component. Antibodies to IpaB were effective across

conclusionsThis quadrivalent MAPS

Indexed as

IpaBMAPS vaccineOSPquadrivalentShigella

Identifiers

PMID39460258
PMCPMC11510904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.