Evidence map›Paper›PMID 39459936›Full record

ArticleViruses2024

Exploring Dengue Infection in a Vaccinated Individual: Preliminary Molecular Diagnosis and Sequencing Insights.

Talita Émile Ribeiro Adelino, Sílvia Helena Sousa Pietra Pedroso, Maurício Lima, Luiz Marcelo Ribeiro Tomé, Natália Rocha Guimarães, Vagner Fonseca, Paulo Eduardo de Souza da Silva, Keldenn Melo Farias Moreno, Ana Cândida Araújo E Silva, Náthale Rodrigues Pinheiro and 4 more

Abstract readCase Reports
In one paragraph

Article in Viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Diagnostic Techniques for Dengue Virus.Current topics in microbiology and immunology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Talita Émile Ribeiro AdelinoFundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil.ORCID 0000-0002-1471-0084
Sílvia Helena Sousa Pietra PedrosoFundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil.
Maurício LimaFundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil.
Luiz Marcelo Ribeiro ToméFundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil.
Natália Rocha GuimarãesFundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil.ORCID 0000-0002-9859-5895
Vagner FonsecaDepartment of Exact and Earth Science, University of the State of Bahia, Salvador 41192-010, Brazil.ORCID 0000-0001-5521-6448
Paulo Eduardo de Souza da SilvaFundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil.ORCID 0009-0003-5640-3626
Keldenn Melo Farias MorenoFundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil.
Ana Cândida Araújo E SilvaComitê Técnico Científico Multidisciplinar, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39800-091, Brazil.
Náthale Rodrigues PinheiroComitê Técnico Científico Multidisciplinar, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni 39800-091, Brazil.ORCID 0000-0003-4521-9121
Carolina Senra Alves de SouzaSecretaria Estadual de Saúde de Minas Gerais, Belo Horizonte 31630-900, Brazil.
Luiz Carlos Junior AlcantaraInstituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-009, Brazil.ORCID 0000-0002-6769-9931
Marta GiovanettiInstituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte 30190-009, Brazil.ORCID 0000-0002-5849-7326
Felipe Campos de Melo IaniFundação Ezequiel Dias, Belo Horizonte 30510-010, Brazil.ORCID 0000-0002-3629-8529

Funding

University of Washington Arboviral Research Network (UWARN)U01AI151698 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale, PETER MACGARR RABINOWITZ · 2020 to 2026
$13.3M
Brazilian Ministry of Health SCON2021-00180CRP-ICGEB RESEARCH CRP/BRA20-03FAPEMIG RED-00234-23Fiocruz/Oswaldo Cruz Foundation Programa InovaNIAID NIH HHS U01 AI151698NIH HHS 1U01AI151698-24A1
6 · The paper itself

Abstract

This study examines a case involving a 7-year-old child who developed dengue symptoms following Qdenga vaccination. Despite initial negative diagnostic results, molecular analysis confirmed an infection with DENV4. Next-generation sequencing detected viral RNA from both DENV2 and DENV4 serotypes, which were identified as vaccine-derived strains using specific primers. Phylogenetic analysis further confirmed that these sequences belonged to the Qdenga vaccine rather than circulating wild-type viruses. This case underscores the critical need for precise diagnostic interpretation in vaccinated individuals to avoid misdiagnosis and to strengthen public health surveillance. A comprehensive understanding of vaccine-induced viremia is essential for refining dengue surveillance, improving diagnostic accuracy, and informing public health strategies in endemic regions.

Indexed as

DengueDengue VaccinesDengue VirusHigh-Throughput Nucleotide SequencingPhylogenyRNA, ViralChildHumansMaleSerogroupVaccinationDengue VaccinesRNA, ViralDENV monitoringgenomic surveillancenext-generation sequencingvaccine breakthrough

Identifiers

PMID39459936
PMCPMC11512295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.